Device for non-invasive measurement of blood sugar level
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Publication Number
US-10278622-B2
Publication Date
2019-05-07
Expiration Date
Abstract
The object of the invention is a device that allows measuring blood sugar levels in mammals—primarily humans—by measuring the refraction of electromagnetic radiation from the skin or body tissue, without the need for invasive sampling, such as penetrating or pricking the skin. The device uses the blue light portion of the visible spectrum and near-infrared (IR) radiation as a source of electromagnetic radiation. The device falls within the field of medical diagnostics and is essentially designed to be portable, so that the users can wear it on their wrists, for example. The signals of reflected light/radiation measured by the sensor unit are filtered by the frequency filtering set and mathematically processed in order to Calculate the current blood sugar level. The accuracy of the measurement result of the device is comparable to the results obtained with the standard method of measuring by blood sampling. A method for measuring of blood sugar level using said device is also disclosed.
Core Innovation
A device for non-invasive measurement of blood sugar levels in mammals, preferably humans, measures electromagnetic radiation reflected from the skin and/or tissue. The device includes a blue light source with a wavelength of 430 nm to 480 nm and an infrared radiation source with a wavelength of 700 nm to 3000 nm, and a sensor unit measures the reflected blue light and infrared radiation and converts them into a change in resistance or electrical current or voltage.
The device uses a frequency filtering set for signal filtering that filters out all frequencies of the signal except for a determined frequency band around and including the blue light pulsation frequency F_B when measuring blue light, and a determined frequency band around and including the IR radiation pulsation frequency F_IR when measuring IR radiation. Excitation of the blue light source is controlled with the pulsation frequency F_B and a blue excitation time interval T_B, and excitation of the IR radiation source is controlled with the pulsation frequency F_IR and an IR excitation time interval T_IR.
From individual measuring intervals, the processing unit captures searched signal values from the filtered signal separately for the blue light and separately for the IR radiation. Based on the searched signal values, the processing unit calculates the blood sugar level using a preset mathematical algorithm, including searched signal values represented by U_Bmax, U_Bmin, U_IRmax, and U_IRmin together with empirical constants K1 and K2 to determine intermediate variables X1 and X2 and to calculate an blood sugar level AG as a function of K1, X1, X2, and K2.
Claims Coverage
The document explicitly provides one independent claim directed to a non-invasive blood sugar measurement device using reflected blue and IR electromagnetic radiation, frequency filtering around pulsation frequencies, and a preset mathematical algorithm based on searched signal values. The independent claim defines six inventive features spanning radiation sources, reflective sensing with electrical conversion, frequency filtering, controlled pulsed excitation parameters, and calculation from searched signal values.
Non-invasive reflected radiation blood sugar measurement
A device for non-invasive measurement of blood sugar levels in mammals, preferably humans, by measuring electromagnetic radiation reflected from the skin and/or tissue using a blue light source and an infrared radiation source.
Blue and infrared sources for reflection measurement
A blue light source with a wavelength of 430 nm to 480 nm and an infrared radiation source with a wavelength of 700 nm to 3000 nm, wherein reflected radiation from the skin and/or tissue is measured.
Reflective sensing with electrical conversion
A sensor unit for measuring blue light and infrared radiation reflected from the skin and/or tissue and converting them into a change in resistance or electrical current or voltage.
Frequency filtering around pulsation frequencies
A frequency filtering set comprising one or more analog and/or digital frequency filters that filter out all frequencies of the signal except for a determined frequency band around and including the blue light pulsation frequency F_B when measuring blue light, and around and including an IR radiation pulsation frequency F_IR when measuring IR radiation.
Pulsed excitation control for blue and IR measurement intervals
A processing unit that controls excitation of the blue light source with pulsation frequency F_B and excitation time interval T_B, and controls excitation of the IR radiation source with pulsation frequency F_IR and excitation time interval T_IR.
Preset algorithm calculation from searched signal values
The processing unit captures searched signal values from the filtered signal separately for the blue light and separately for the IR radiation in individual measuring intervals, and calculates the blood sugar level using a preset mathematical algorithm from the searched signal values.
Overall, the claim coverage is centered on a non-invasive device that emits blue and IR radiation, measures reflected radiation with a sensor converting it to an electrical change, isolates pulsation components via frequency filtering around F_B and F_IR, captures searched signal values in separate measuring intervals, and computes blood sugar using a preset mathematical algorithm.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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