Multifunctional transdermal dressing for wounds
Inventors
Rangan, Krishnaswamy Kasthuri • Sudarshan, Tirumalai Srinivas
Assignees
Publication Number
US-10272172-B2
Publication Date
2019-04-30
Expiration Date
2034-03-13
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Abstract
A multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic. The multifunctional polymer-free clay product provides antimicrobial and pain relieving properties. Method of treatment of burns using the multifunctional polymer-free clay product having antimicrobial and pain relieving properties. Methods of preparing multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic.
Core Innovation
The invention provides a multifunctional, polymer-free clay film or mat that serves as a wound dressing with both antimicrobial and pain-relieving properties. This product comprises a clay, a zwitterion (such as betaine or its hydrochloride), an antimicrobial agent (such as silver ion, copper, or their compounds), and an analgesic (including opioids like fentanyl, nonsteroidal anti-inflammatory drugs, and local anesthetics like lidocaine base). The film is prepared without any added polymer, thereby utilizing the intrinsic properties of the clay as both the structural matrix and drug delivery medium.
The problem addressed is the need for an effective wound and burn dressing, especially for scenarios such as battlefield injuries, which can provide both infection control and local pain relief. Conventional treatments often rely on systemic opioid administration, which can cause undesirable effects such as tolerance, respiratory depression, and dependence. There is also a need to avoid dose dumping and ensure reliable, controlled delivery of analgesics and antimicrobials directly to the wound site. Existing wound dressings may suffer from poor mechanical stability or may rely on polymers, which can impede drug release or skin permeability.
The disclosed method details the incorporation of antimicrobial agents and analgesics into a clay mat, with specific manufacturing steps that result in a flexible, thin, and continuous film capable of being cut or rolled to desired sizes. The film can be produced in varying thicknesses and demonstrates both physical flexibility and drug delivery functionality. Specific drug loading methods and control over mechanical and release properties are described. The innovation includes variants with backing films and diffusion membranes, and defines the precise sequence of material addition and preparation steps essential for efficacy.
Claims Coverage
There are two independent claims focusing on the method of preparing a multifunctional polymer-free clay film and the multifunctional polymer-free clay film itself. The main inventive features are the specific multi-step method of preparation and the composition of the resulting film.
Preparation of polymer-free clay film with antimicrobial and analgesic properties
The method comprises: 1. Mixing a clay, an antimicrobial agent, and water to form a slurry. 2. Centrifuging and washing the slurry with water to obtain a washed slurry. 3. Adding a zwitterion and water to the washed slurry to form a third slurry. 4. Casting the third slurry onto a substrate to obtain a first dried product. 5. Adding drops of the analgesic (in a non-aqueous solvent) onto the first dried product to form a resultant product. 6. Drying the resultant product to obtain a second dried product. 7. Separating the second dried product from the substrate, resulting in a multifunctional, polymer-free clay film. Key features include the use of zwitterions selected from N,N,N-trimethylglycine or its hydrochloride and antimicrobial agents chosen from silver ion, copper, silver-containing compounds, and copper-containing compounds.
Multifunctional polymer-free clay film providing antimicrobial and pain relieving properties
The product is a multifunctional, polymer-free clay film that: - Is prepared by the above method steps. - Comprises a clay, a zwitterion, an antimicrobial agent, and an analgesic. - Provides both antimicrobial and pain relieving properties without the inclusion of polymers.
The claims primarily cover both the specific preparation process of a polymer-free clay film containing defined antimicrobials and analgesics and the resultant multifunctional film having those properties.
Stated Advantages
Provides both antimicrobial and pain relieving properties in a single, polymer-free clay product.
Allows for controlled delivery of analgesic drugs to wounds, aiding wound healing and reducing pain locally.
Reduces the risk of 'dose dumping' compared to conventional polymer- or textile-based drug delivery systems.
Demonstrates mechanical and chemical stability, enabling use as a flexible and conformable wound dressing.
Avoids the use of polymers, ensuring optimal permeability for drugs and moisture while maintaining clay’s beneficial properties.
Documented Applications
Wound and burn dressings for delivering both antimicrobial treatment and pain relief.
Treatment of burns, including battlefield and civilian burn injuries.
Dressings for pain management at skin graft donor sites.
Antimicrobial dressings for infections in wounds and surgical care.
Hemostatic dressings to stop bleeding and promote wound healing.
Use in water filtration systems.
Use in food packaging.
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