Antimicrobial silver hydrogel composition for the treatment of burns and wounds
Inventors
Yates, Kenneth M • Proctor, Celia A • Atchley, Dan H
Assignees
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Publication Number
US-10272108-B2
Publication Date
2019-04-30
Expiration Date
Abstract
An antimicrobial therapeutic hydrogel composition comprises a pharmaceutical and/or medical grade silver salt, and an Aloe vera gel or extract. The composition could also include stabilizing agents, a non-ionic surfactant, polyol, and hydrophilic hygroscopic polymers. The resulting product has potent antimicrobial activity against bacteria, protozoa, fungi and viruses. The antimicrobial therapeutic composition can serve as a treatment for burns and as a wound/lesion dressing that either donates or receives moisture to provide a physiologic environment for accelerated wound healing and the relief of pain.
Core Innovation
The patent describes an antimicrobial silver-containing therapeutic hydrogel comprising a soluble silver salt stabilized as anhydrous or hydrous, an acemannan, and a stabilizing chelating agent. The hydrogel is formulated with ionic silver in a stated concentration range and acemannan in a stated weight percentage range, with the chelating agent also present within a stated weight percentage range. The chelating agent is EDTA, EGTA, or mixtures thereof.
The document describes the hydrogel as a wound, lesion, or burn dressing that provides antimicrobial activity while serving a dressing function associated with moist wound healing and creation of a physiologic healing environment. The antimicrobial activity is stated to extend broadly across microorganisms including bacteria, yeast, protozoa, fungi, and viruses, and the dressing function is described as donating and receiving moisture to support a healing environment.
In the disclosed examples and comparisons, a silver antimicrobial hydrogel containing silver citrate together with acemannan is compared to silver citrate alone using MIC results, showing improved antimicrobial performance. The document also reports comparative performance versus marketed drugs including miconazole and silver sulfadiazine, and describes observed pain relief and accelerated wound healing outcomes in described cases involving wounds, burns, and a herpes labialis example.
Claims Coverage
The independent claim covers an antimicrobial hydrogel defined by three mandatory formulation components: a stabilized soluble silver salt with ionic silver in a defined range, acemannan in a defined range, and a stabilizing chelating agent that is EDTA or EGTA. Dependent claim refinements specify preferred silver salt options, acemannan form, buffering pH, antimicrobial activity targets, and a treatment method.
Stabilized soluble silver salt with ionic silver
An anhydrous or hydrous stabilized soluble silver salt having a concentration of ionic silver in the range of 0.01-100 ppm.
Acemannan in defined concentration
Acemannan wherein the acemannan has a concentration of 0.01 to 1.0 w/w %.
Stabilizing chelating agent EDTA or EGTA
A stabilizing chelating agent having a concentration of 0.01 to 5.0 w/w %, wherein the stabilizing chelating agent is EDTA, ethylene glycol tetraacetic acid (EGTA), or mixtures thereof.
Chelated acemannan with specified silver salt options
The soluble silver salt is selected from the group consisting of silver citrate, silver dihydrogen citrate, silver chloride, silver acetate, silver nitrate, silver fusidate, silver benzoate, silver gluconate, and silver galacturonate.
Acemannan in anhydrous separated form
The acemannan has an anhydrous form and was separated using an alcohol precipitation method, a column purification method, or an ultrafiltration method in an aqueous vehicle.
Buffered pH range
The antimicrobial hydrogel is buffered to a pH of 4-7.4.
Antimicrobial activity against specified organisms
The antimicrobial hydrogel has antimicrobial activity against E. coli, P. aeruginosa, and S. aureus.
Treatment method using physiologic healing environment
A method for treating a wound, lesion, or burn by topically applying an effective amount of the antimicrobial hydrogel to accelerate wound healing by creating a physiologic healing environment.
Overall claim coverage centers on a hydrogel composition that combines stabilized soluble ionic silver, acemannan, and a chelating agent, with dependent features refining specific silver salt options, acemannan form and separation, buffering pH, defined antimicrobial activity targets, and a treatment method tied to accelerated wound healing via a physiologic healing environment.
Stated Advantages
Broad antimicrobial activity against microorganisms including bacteria, yeast, protozoa, fungi, and viruses.
Moist wound healing by donating and receiving moisture as a dressing function.
Creation of a physiologic healing environment.
Pain relief.
Accelerated wound healing.
Documented Applications
Wound dressing use for treating wounds, lesions, or burns by topically applying an antimicrobial hydrogel to accelerate wound healing.
Use as a burn dressing, including first-degree burn in described cases.
Treatment case involving an equine laceration as described.
Use case described for herpes labialis (HSV) with reported pain reduction and improved healing.
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