Medical fluid, a method of treatment and use of the fluid
Inventors
Assignees
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Publication Number
US-10271540-B2
Publication Date
2019-04-30
Expiration Date
Abstract
A medical fluid for a harvested organ, tissue or part thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analog thereof; noradrenaline; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenaline; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.
Core Innovation
The invention relates to a method for preservation and/or evaluation of a harvested organ in which a medical fluid is circulated in the vascular system of the harvested organ. The harvested organ is at least partly denervated, and the medical fluid comprises cocaine or a cocaine analogue with stimulating effect, adrenaline, and noradrenaline. Cocaine or the cocaine analogue is present at a concentration of 0.010 b5M to 0.100 b5M.
The problem being solved is that harvested, at least partly denervated organs are affected by catecholamine depletion that leads to loss of vasotonus and edema, which is associated with post-transplant complications. The core solution is to maintain vasotonus and counteract edema by adding adrenaline and noradrenaline to the medical fluid together with cocaine or a cocaine analogue with stimulating effect.
The partial content further explains that the potentiating effect is associated with the action of cocaine, described as a NET inhibitor, and that the intent is to improve post-transplant outcomes while reducing edema and, in embodiments, cardiac/pulmonary complications.
Claims Coverage
Independent claim clm-00001 sets out three inventive features for a preservation and/or evaluation method for at least partly denervated harvested organs.
Circulating a vascular medical fluid in a harvested, partly denervated organ
A method for preservation and/or evaluation of a harvested organ comprises circulating a medical fluid in the vascular system of the harvested organ, wherein the harvested organ is at least partly denervated.
Cocaine (or stimulant cocaine analogue) plus adrenaline and noradrenaline
The medical fluid comprises cocaine or a cocaine analogue with stimulating effect, adrenaline, and noradrenaline.
Cocaine concentration of 0.010 b5M to 0.100 b5M
Cocaine or the cocaine analogue is present in the medical fluid at a concentration of 0.010 b5M to 0.100 b5M.
The independent claim combines vascular circulation of a medical fluid for preservation and/or evaluation of an at least partly denervated harvested organ with a catecholamine-containing fluid including cocaine or a stimulating analogue, and limits the cocaine or analogue concentration to 0.010 b5M to 0.100 b5M.
Stated Advantages
Maintains vasotonus in a partially denervated organ.
Improves post-transplant outcomes.
Reduces edema.
Reduces cardiac/pulmonary complications in embodiments.
Documented Applications
Preservation and/or evaluation of a harvested organ by circulating the medical fluid in the vascular system of the harvested organ.
Embodiments narrow the harvested organ to lung(s) or heart.
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