Radiopaque monomers, polymers, microspheres, and methods related thereto
Inventors
Assignees
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Publication Number
US-10265423-B2
Publication Date
2019-04-23
Expiration Date
Abstract
Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
Core Innovation
The invention relates to radiopaque monomers of Formula I, where n is 0-12 and R is either an oxygen-containing moiety or a nitrogen-containing moiety, that are polymerized to form polymer microspheres. The polymer microspheres include at least one specified polymerized component selected from polymerized N-[Tris(hydroxymethyl)methyl] acrylamide, polymerized diethyl aminoethyl acrylamide, or polymerized triethyl aminoethyl acrylamide. The resulting microspheres are described as detectable without a separate contrast agent because of their radiopacity.
The microspheres are further described as having controlled properties such as non-/resorbability and swellable or shrinkable behavior. The content provides microsphere size ranges, and it characterizes changes in microsphere size as a function of environmental conditions including pH and NaCl. Radiopacity is described in relation to reference materials, and the polymer microspheres are evaluated using imaging such as CT scan and X-ray, including comparisons to metallic stents.
In additional embodiments, the microspheres can incorporate cross-linkers and other agents including radiopaque agents, magnetic/MRI agents, coloring agents, and therapeutic agents such as doxorubicin. The document describes applications in which microspheres are used for embolization and tracked by imaging, including examples of in vivo pig liver embolization where the microspheres are detectable without separate contrast agent, with radiopacity and CT imaging results reported.
Claims Coverage
The provided independent claims are directed to a polymer microsphere containing a polymerized monomer of Formula I with specified amino-acrylamide components, and to a non-resorbable version of such a microsphere. Across these two independent claims, the main inventive features are structured polymer composition based on Formula I with specified amino-containing acrylamide components, and non-resorbability.
Polymer microsphere with Formula I monomer composition
A microsphere comprising a polymer, wherein the polymer comprises a polymerized monomer of Formula I, wherein n is 0-12 and wherein R is either an oxygen-containing moiety or a nitrogen-containing moiety.
Amino-acrylamide polymerized component in the microsphere polymer
A microsphere comprising a polymer, wherein the polymer further comprises at least one of a polymerized N-[Tris(hydroxymethyl)methyl] acrylamide, a polymerized diethyl aminoethyl acrylamide, or a polymerized triethyl aminoethyl acrylamide.
Non-resorbable microsphere with Formula I monomer composition
A microsphere comprising a polymer, wherein the polymer comprises a polymerized monomer of Formula I, wherein n is 0-12 and wherein R is either an oxygen-containing moiety or a nitrogen-containing moiety, wherein the polymer further comprises a polymerized N-[Tris(hydroxymethyl) methyl] acrylamide, and wherein the microsphere is non-resorbable within a patient's body.
The independent claims define polymer microspheres whose polymer is based on a polymerized monomer of Formula I and that further include specified polymerized amino-acrylamide components. The second independent claim additionally limits the microsphere to be non-resorbable within a patient's body.
Stated Advantages
Microspheres are detectable without a separate contrast agent because of their radiopacity.
Documented Applications
Embolization by injecting the microsphere into a patient's blood vessel.
Tracking and surveillance by imaging, including imaging performed without a contrast agent being present at the microsphere location at the time of imaging.
In vivo pig liver embolization with radiopacity/CT imaging results described without separate contrast agent.
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