Systems and methods for producing gastrointestinal tissues
Inventors
La Francesca, Saverio • Soliman, Sherif • Marsh, Matthew
Assignees
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Publication Number
US-10265153-B2
Publication Date
2019-04-23
Expiration Date
Abstract
Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
Core Innovation
The invention provides a method for guided tissue growth in a subject after resecting a portion of a tubular organ. The resection step produces a resected organ portion that remains in the subject at a resection site and includes tissue having at least one resection edge. A synthetic scaffold is implanted at the resection site to support guided tissue growth along the scaffold.
The synthetic scaffold includes a body section having an outer polymeric surface and a cellularized sheath layer overlying at least a portion of the outer polymeric surface of the body section. The scaffold is maintained at the resection site for a period of time sufficient to achieve guided tissue growth derived from and in contact with the tissue present in the resected organ portion remaining in the subject.
After guided tissue growth is achieved, the scaffold is removed in a manner that keeps the guided tissue growth in contact with the resected organ portion remaining in the subject. The removal step is achieved intrascopically, allowing the guided tissue growth to remain connected to the remaining tubular organ tissue while the scaffold is removed.
Claims Coverage
The independent claim family describes four core inventive actions: resection while leaving a tubular organ portion in the subject, implantation of a synthetic scaffold with a cellularized sheath layer, time-controlled maintenance to achieve guided tissue growth from and in contact with the remaining resected tissue, and intrascopic removal of the scaffold while keeping the guided tissue growth in contact with the remaining organ tissue. Inventive features are centered on scaffold architecture and the intrascopic removal step after guided growth is achieved.
Resection and remaining tubular organ portion at a resection site
Resecting a portion of a tubular organ in a subject, producing a resected organ portion that remains in the subject at a resection site and has tissue with at least one resection edge.
Synthetic scaffold body section with cellularized sheath layer
Implanting a synthetic scaffold at the resection site, the synthetic scaffold including a body section having an outer polymeric surface and a cellularized sheath layer overlying at least a portion of the outer polymeric surface of the body section.
Guided tissue growth derived from and in contact with remaining resected tissue
Maintaining the synthetic scaffold at the resection site for a period of time sufficient to achieve guided tissue growth along the synthetic scaffold, the guided tissue growth derived from and in contact with the tissue present in the resected organ portion remaining in the subject.
Intrascopic removal preserving contact with guided tissue growth
After achieving guided tissue growth, removing the synthetic scaffold from the implantation site in a manner such that the guided tissue growth remains in contact with the resected organ portion of the tubular organ remaining in the subject, wherein the removing step is achieved intrascopically.
Across the independent claim, the central inventive coverage is a scaffold-supported, contact-dependent guided tissue growth process anchored to a resected tubular organ portion that remains in the subject, followed by intrascopic scaffold removal that preserves contact between the guided tissue growth and the remaining organ tissue.
Stated Advantages
Minimal scaffold incorporation and evidence of tissue differentiation associated with the regeneration.
Documented Applications
Guided regeneration in the esophagus.
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