Collagen-containing wound dressing and method for the production thereof
Inventors
Bielenstein, Oliver • Tadic, Drazen
Assignees
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Publication Number
US-10251972-B2
Publication Date
2019-04-09
Expiration Date
Abstract
A wound dressing and a method for production thereof. The wound dressing includes a collagen-containing sheet-like structure, which is made of magnesium or a magnesium alloy. The sheet-like structure has openings and is embedded in a collagen-containing sheet-like structure. The wound dressing is embodied as a geometrically stable bioresorbable membrane and includes a support made of a collagen membrane, on which the collagen-containing sheet-like structure is arranged.
Core Innovation
The invention provides a method for producing a geometrically stable bioresorbable wound dressing membrane. A sheet-like structure made of magnesium or a magnesium alloy is covered with a collagen-containing preparation, the collagen-containing preparation is dried, and the sheet-like structure is applied onto a support comprising a collagen membrane.
The collagen-containing preparation forms a collagen-containing sheet-like structure that is dried to produce a collagen non-woven fabric or collagen fluff. The magnesium or magnesium alloy sheet-like structure is embedded in the collagen-containing sheet-like structure, and the resulting composite wound dressing membrane is geometrically stable and bioresorbable.
The disclosed membrane is configured for use in bent states, including curved configurations intended to prevent rolling off or sinking in bent-use applications. Optional features described include passivation layers on magnesium, improved bonding through texturing and/or pocketing between collagen membranes, and cohesion enhancement via suturing or gluing.
Claims Coverage
The document includes two independent claims. The claims center on embedding a magnesium or magnesium alloy sheet-like structure within a collagen-containing sheet-like structure and arranging the resulting structure on a collagen membrane support to obtain a geometrically stable bioresorbable membrane.
Covering magnesium sheet with collagen-containing preparation and drying
Covering a sheet-like structure made of magnesium or a magnesium alloy with a collagen-containing preparation, drying the collagen-containing preparation, and applying the sheet-like structure onto a support comprising a collagen membrane.
Magnesium openings embedded in collagen sheet on collagen membrane support
A wound dressing comprising a collagen-containing sheet-like structure, a sheet-like structure made of magnesium or a magnesium alloy comprising openings, embedded in the collagen-containing sheet-like structure, and a support made of a collagen membrane on which the collagen-containing sheet-like structure is arranged, wherein the wound dressing comprises a geometrically stable bioresorbable membrane.
Across the independent claims, the main inventive contribution is the formation of a geometrically stable bioresorbable membrane by embedding a magnesium or magnesium alloy sheet-like structure within a collagen-containing sheet-like structure and arranging the resulting collagen-containing structure on a collagen membrane support, with the product claim additionally requiring openings in the magnesium or magnesium alloy sheet-like structure.
Stated Advantages
Prevents the dressing from rolling off or sinking in bent-use applications.
Provides a geometrically stable bioresorbable membrane in bent state.
Documented Applications
Bend-use applications such as jaw/bone defect sites.
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