Nutritional supplements containing a peptide component and uses thereof
Inventors
van Tol, Eric A. F. • Schoemaker, Marieke H. • Gross, Gabriele • Lambers, Teartse Tim • Wielinga, Peter • Kleemann, Robert
Assignees
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Publication Number
US-10251928-B2
Publication Date
2019-04-09
Expiration Date
Abstract
The present disclosure relates to nutritional supplement including a peptide component. The nutritional supplement further includes a source of long-chain polyunsaturated fatty acids and Lactobacillus rhamnosus GG. The disclosure further relates to methods of protecting against obesity and its related metabolic disorders and inflammatory diseases in a target subject by providing the nutritional supplement(s) disclosed herein to a target subject, which includes a pediatric subject.
Core Innovation
The invention relates to a nutritional supplement comprising a source of long-chain polyunsaturated fatty acid, Lactobacillus rhamnosus GG, and a protein equivalent source comprising partially hydrolyzed proteins and intact proteins. The protein equivalent source is characterized by a peptide component fraction and a partially hydrolyzed protein fraction, each present as 20% to 80% of the protein equivalent source.
The peptide component comprises a defined set of individual peptides identified by SEQ ID NO: 4, 13, 17, 21, 24, 30, 31, 32, 51, 57, 60, and 63. The partially hydrolyzed proteins can be further specified by a degree of hydrolysis of less than 40%.
The long-chain polyunsaturated fatty acid can include docosahexaenoic acid and/or arachidonic acid, as further defined in dependent coverage. The disclosure additionally describes use contexts for metabolic and inflammatory disorders, including obesity, type 2 diabetes, cardiovascular disease, hepatosteatosis, impaired cognition, and kidney function.
Claims Coverage
Independent claim coverage describes one nutritional supplement with three co-occurring components and two main quantitative distribution features, together with a defined peptide set.
Defined nutritional supplement with long-chain polyunsaturated fatty acid, Lactobacillus rhamnosus GG, and protein equivalent source
A nutritional supplement comprising a source of long-chain polyunsaturated fatty acid, Lactobacillus rhamnosus GG, and a protein equivalent source comprising partially hydrolyzed proteins and intact proteins.
Peptide-component fraction with a defined set of SEQ ID NO peptides
20% to 80% of the protein equivalent source includes a peptide component, wherein the peptide component comprises SEQ ID NO: 4, 13, 17, 21, 24, 30, 31, 32, 51, 57, 60, and 63.
Partially hydrolyzed protein fraction as a complementary 20% to 80% component
20% to 80% of the protein equivalent source comprises partially hydrolyzed proteins.
The inventive concept centers on a nutritional supplement combining a long-chain polyunsaturated fatty acid source, Lactobacillus rhamnosus GG, and a protein equivalent source with a peptide component containing the enumerated SEQ ID NO peptides and a partially hydrolyzed protein fraction.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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