Ready-to-use storable methanolic solution of a biocompatible and biocidal polyvinylpyridine polymer
Inventors
BOULOUSSA, Houssam • Bouloussa, Othman
Assignees
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Publication Number
US-10238110-B2
Publication Date
2019-03-26
Expiration Date
Abstract
An alcoholic solution of a partially quaternarized polyvinylpyridine polymer is provided. The alcoholic solution has biocidal and biocompatibility properties. The alcoholic solution is ready-to-graft in order to confer biocidal properties on various surfaces and to prevent biofilm formation on such surfaces.
Core Innovation
The invention relates to an alcoholic solution comprising a polyvinylpyridine polymer of formula I or formula II, wherein X is 12±2% to 45±2%. The polyvinylpyridine polymer is partially quaternarized and is provided as a ready-to-use, storable methanolic/alcoholic solution.
A key aspect is that stability for prolonged storage is achieved by using a partially quaternarized polyvinylpyridine statistical copolymer with a specified N+N ratio (X). The stability is attributed to controlling the target N+N ratio and preventing volume reticulation during storage through the selection of the polymer-forming reactants and their proportions.
The document further discloses polyvinylpyridine polymers formed by reacting polyvinylpyridine with functional reactants corresponding to monomer A and monomer B in an alcoholic solvent for a reaction period of about two days, yielding a statistical copolymer. The resulting material combines biocidal activity with biocompatibility and is described as inhibiting biofilm formation, including for MRSA, while also showing cytocompatibility in MTT-based biocompatibility testing on L929 fibroblasts and MC3T3 osteoblast precursor cells.
The invention is also described as enabling grafting/covalent bonding onto activated surfaces, with titanium being notably mentioned. The document additionally notes an application potential to wood through grafting on cellulose.
Claims Coverage
The independent claim covers an alcoholic solution containing a polyvinylpyridine polymer of formula I or formula II with X in the range 12±2% to 45±2%. The dependent claims narrow X to 44±2% and add biocompatibility, and they further specify polymer formation by reacting polyvinylpyridine with chloromethylcatechol/bromobutane or iodopropyltrimethoxysilane/bromobutane, including a one-step reaction in methanol or ethanol carried out for two days.
Alcoholic solution with polyvinylpyridine polymer of formula I or formula II
An alcoholic solution comprising a polyvinylpyridine polymer of formula I or formula II, wherein X is 12±2% to 45±2%.
Specified N+N ratio (X)
The alcoholic solution of claim 1 is characterized by having X equal to 44±2%.
Biocompatible polyvinylpyridine polymer
The alcoholic solution in which the specified polyvinylpyridine polymer is biocompatible.
Copolymer of formula I from chloromethylcatechol and bromobutane
An alcoholic solution in which the polymer of formula I is produced as a copolymer by reacting polyvinylpyridine, chloromethylcatechol, and bromobutane.
Copolymer of formula II from iodopropyltrimethoxysilane and bromobutane
An alcoholic solution in which the polymer of formula II is a copolymer obtained by reacting polyvinylpyridine, iodopropyltrimethoxysilane and bromobutane.
One-step reaction in alcoholic solvent for about two days
An alcoholic solution containing a copolymer prepared via a one-step process reaction in an alcoholic solvent (methanol or ethanol) carried out for two days.
Overall, the claim set centers on an alcoholic solution comprising a partially quaternarized polyvinylpyridine polymer of formula I or formula II with a controlled N+N ratio X. The dependent claims specify X as 44±2%, add biocompatibility, and define how the copolymers are obtained from defined functional reactants (chloromethylcatechol/bromobutane or iodopropyltrimethoxysilane/bromobutane), including a one-step reaction in methanol or ethanol for about two days.
Stated Advantages
Provides stability for prolonged storage.
Prevents volume reticulation during storage.
Provides biocidal activity.
Provides biocompatibility.
Inhibits biofilm formation, including MRSA anti-biofilm activity.
Documented Applications
Grafting/covalent bonding of the solution onto activated surfaces, notably titanium.
Application potential to wood via grafting on cellulose.
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