Compositions and methods for controlling carbohydrate and fat metabolism

Inventors

Peltier, Sebastien • Sirvent, Pascal • Maugard, Thierry

Assignees

Centre National de la Recherche Scientifique CNRS • La Rochelle Universite • Universite Clermont Auvergne • Valbiotis SA

Abstract

A composition comprising at least a mixture of molecules obtained at least from: Chrysanthellum indicum, Cynara scolymus, and Vaccinium myrtillus and wherein the mixture of molecules also comprises piperine. The composition is particularly useful as a nutritional product or health product for preventing and/or combating carbohydrate and/or fat metabolism disorders in humans and animals.

Core Innovation

The invention relates to synergistic multi-target compositions for preventing and treating carbohydrate metabolism disorders and fat metabolism disorders, including type 2 diabetes and related cardio-metabolic risks. The compositions are based on an extract obtained from a blend of at least Chrysanthellum indicum, Cynara scolymus, and Vaccinium myrtillus, combined with piperine and/or extracts from Piper and Olea europaea. The composition further comprises specified sets of molecules belonging to flavonoids and polyphenols, and also comprises at least one of oleuropein, hydroxytyrosol, and analogs thereof.

A central feature is the inclusion of piperine together with defined extracts and multiple named active molecules, including apigenin 7-O-glucuronide, chrysanthellin A, chrysanthellin B, caffeic acid, luteolin variants, maritimetin, eriodictyol variants, isookanin, apigenin and luteolin glycosides, shaftoside, vicenin-2, and dicaffeoylquinic acid and sulfo-monocaffeoylquinic acid. The invention also includes a second set of named anthocyanidins and anthocyanidin glycosides, selected among delphinidin, cyanidin, petunidin, peonidin, malvidin forms, and analogs thereof.

The disclosure supports synergistic activity for key combinations identified as synergistic factors, including Colby synergistic factor, and includes comparative results showing improved metabolic outcomes in db/db mice versus metformin for a composition referenced as C10. Mechanistic support includes increased hepatic AMPK, and in vitro inhibition of carbohydrate and lipid metabolism enzymes including HMG-CoA reductase, alpha-glucosidase, and DPP-IV by compositions referenced as C10/C11/C12.

Claims Coverage

The independent claim covers a multi-target composition in multiple pharmaceutical presentation forms and defines the inventive combination of specific plant extracts and specified molecule sets, including piperine, with optional inclusion of oleuropein and hydroxytyrosol. Three inventive features are identified across the independent and dependent claims, with further claim scope directed to administration and disorder coverage.

The protected subject matter is concentrated on a defined multi-target composition built from blended Chrysanthellum indicum, Cynara scolymus, Vaccinium myrtillus extracts, combined with Piper and/or piperine and optionally oleuropein and hydroxytyrosol, while also requiring specific flavonoid/polyphenol and anthocyanidin molecule sets. The dependent claims further cover administration to treat specified diabetes, non-alcoholic fatty liver disease including non-alcoholic steatohepatitis, cardiovascular pathology, and insulin-resistance-related disorders, optionally in combination with selected antidiabetic therapeutic agents and with optional formulation add-ins.

Stated Advantages

Documented Applications