Recovery and processing of human embryos formed in vivo
Inventors
CARSON, Sandra Ann • Buster, John E. • Cesario, Moses • Woodard, Steven Paul
Assignees
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Publication Number
US-10213230-B2
Publication Date
2019-02-26
Expiration Date
Abstract
A kit having instructions for use for performing uterine lavage in a female patient includes a uterine lavage catheter configured for insertion into a woman's uterus to remove viable blastocysts from the uterus, and one or more first containers having a sufficient dosage amount of a GnRH antagonist to cause desynchronization of the endometrium of the patient prior to, during and/or following recovery of viable blastocysts from the uterus.
Core Innovation
The invention relates to a kit for removing blastocysts from a woman’s uterus and causing corpus luteum apoptosis to desynchronize the endometrium of the uterus. The kit includes a uterine lavage catheter configured for insertion into the woman’s uterus to remove one or more blastocysts from the uterus, and one or more third containers with a sufficient dosage amount of a composition suitable to cause corpus luteum apoptosis leading to desynchronization of the endometrium of the uterus.
The kit further includes one or more first containers for storing biopsied trophectoderm cells or an inner cell mass recovered from the blastocysts following a biopsy procedure. It also includes one or more second containers for storing and cryopreserving the blastocysts following the biopsy procedure, and the first and second containers each comprise one or more labels for identifying the biopsied trophectoderm cells or inner cell mass and the blastocyst from which the biopsied cells or inner cell mass was removed.
In vivo uterine-lavage based embryo recovery and processing is described together with embryo biopsy for trophectoderm cells or inner cell mass, and subsequent cryopreserving of the blastocysts after biopsy.
Claims Coverage
The partial content provides one independent claim, covering a uterine-lavage blastocyst removal and processing kit with corpus luteum apoptosis induced endometrial desynchronization and container/labeling arrangements for biopsy and cryopreservation.
Uterine lavage catheter for blastocyst removal and endometrial desynchronization
A uterine lavage catheter configured for insertion into the woman's uterus to remove one or more blastocysts from the uterus, together with one or more third containers with a sufficient dosage amount of a composition suitable to cause corpus luteum apoptosis leading to desynchronization of the endometrium of the uterus.
Containers for storing biopsied trophectoderm cells or inner cell mass
One or more first containers for storing biopsied trophectoderm cells or an inner cell mass recovered from the one or more blastocysts following a biopsy procedure.
Containers for storing and cryopreserving blastocysts after biopsy
One or more second containers for storing and cryopreserving the one or more blastocysts following the biopsy procedure.
Labeling scheme identifying biopsied cells or inner cell mass and corresponding blastocyst
The one or more first and second containers each comprise one or more labels for identifying the biopsied trophectoderm cells or the inner cell mass and the one or more blastocyst from which they were removed.
Overall, the claim coverage centers on a kit that combines uterine lavage blastocyst removal with a composition suitable to cause corpus luteum apoptosis for endometrial desynchronization, and integrates biopsy storage, labeling, and cryopreservation containers for the corresponding blastocysts.
Stated Advantages
Desynchronization of the endometrium of the uterus via corpus luteum apoptosis.
Documented Applications
Removing one or more blastocysts from a woman’s uterus using in vivo uterine-lavage based embryo recovery and processing, including biopsy of trophectoderm cells or inner cell mass and subsequent cryopreserving of the blastocysts.
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