Compositions and methods for tissue regeneration
Inventors
Assignees
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Publication Number
US-10188672-B2
Publication Date
2019-01-29
Expiration Date
Abstract
Methods and compositions using an orthosilicate for tissue regeneration, such as to treat a disease or condition, are described, including on the skin. Also described are methods for making such compositions.
Core Innovation
The invention concerns orthosilicate-based compositions using Si(OR)4, including tetraethyl orthosilicate, combined with plant-derived oils. The disclosed formulations include tetraethyl orthosilicate together with at least one oil such as jojoba oil, almond oil, cocoa butter, beeswax, sweet almond oil, olive oil, and in some compositions aloe vera oil, with the compositions presented as topical creams or ointments.
The invention is directed to tissue regeneration by treating conditions including acne, puncture wounds, and skin cancers such as melanoma and basal cell carcinoma, and by addressing hair loss. The description provides mechanistic rationale involving innate immune activation, including macrophage-mediated damp and pamp response, connected to the use of non-polymerizing orthosilicates.
The oil component and formulation structure are described as providing protection for the active orthosilicate within the composition. The disclosure additionally describes preparation of the orthosilicate/oil compositions through physical mixing and inclusion of optional formulation excipients, with examples of topical cream or ointment embodiments.
Claims Coverage
The partial claims include two independent claims. Each independent claim centers on a cream or ointment composition that consists essentially of tetraethyl orthosilicate at 25% to 40% by total weight and at least one specified oil, with optional excipients in the broader embodiment.
Tetraethyl orthosilicate with selected oil in cream or ointment
A composition consisting essentially of tetraethyl orthosilicate and at least one oil selected from the group consisting of jojoba oil, almond oil, cocoa butter, bees wax, and sweet almond oil, wherein the tetraethyl orthosilicate is present in a concentration from 25% to 40% by total weight of the composition, and wherein the composition is presented as a cream or an ointment.
Tetraethyl orthosilicate with selected oil and optional components in cream or ointment
A composition consisting of tetraethyl orthosilicate; at least one oil selected from the group consisting of jojoba oil, almond oil, aloe vera oil, olive oil, cocoa butter, bees wax, and sweet almond oil; and optionally one or more components selected from the group consisting of an excipient, stabilizer, moisturizer, thickening agent, emulsifier, emollient, lubricant, surfactant, deodorizing agent, viscosity controlling agent, solvent, softening agent, alkalizing agent, vitamin, opacifying agent, solubilizer, plant extract, water, chelating agent, humectant, thickener, cryoprotectant, biocide, nebulizer, anti-oxidant, lipid, peptide, protein, amino acid, anti-aging agent, anti-wrinkle agent, fragrance, essential oil, and preservative; wherein the tetraethyl orthosilicate is present in a concentration from 25% to 40% by total weight of the composition, and wherein the composition is presented as a cream or an ointment.
Across the independent claims, the inventive coverage is directed to topical cream or ointment formulations that combine tetraethyl orthosilicate at 25% to 40% by total weight with at least one selected plant oil, and in one embodiment optionally include listed excipients and other formulation components.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Treating acne.
Treating puncture wounds.
Treating skin cancers including melanoma.
Treating skin cancers including basal cell carcinoma.
Treating hair loss with hair regrowth.
Improving demodectic mange.
Accelerated wound healing in reported examples.
Improvement of basal cell carcinoma and melanoma lesions in reported examples.
A chronic foot rot case with reduced need for surgery as reported in the disclosure.
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