Nutritional and medicinal oral composition for veterinary use
Inventors
BRUNEL, Nicolas • MARTINS, Fanny • GOISNARD, Patricia
Assignees
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Publication Number
US-10166186-B2
Publication Date
2019-01-01
Expiration Date
Abstract
The invention relates to a method for producing a nutritional and medicinal oral composition for veterinary use, comprising the following steps: a) providing cores of extruded products of complete feed, and b) coating the cores of extruded products of complete feed provided in step a) with at least one layer of a fatty material comprising at least one medicinal agent, said medicinal agent comprising (i) at least one pre-conditioned active substance in the form of a solution or a suspension of said active substance in an oily liquid, or (ii) at least one pre-conditioned active substance in the form of waxy granulates, at a temperature lower than 40° C.
Core Innovation
The invention concerns a method for obtaining a nutritional and medicinal oral composition for veterinary use that uses cores of complete feed extrudate. The method supplies extruded cores and brings them into contact with a medicinal agent selected from a defined group of active principles.
The medicinal agent is provided as at least one active principle in the form of non-encapsulated microparticles, where the active principle is preconditioned either as a solution or a suspension of the active principle in an oily liquid, or as waxy granules. The active principle is selected from angiotensin-converting enzyme inhibitors (ACE inhibitors), renin inhibitors, angiotensin II receptor antagonists, firocoxib, ciclosporin, S-adenosyl-methionine, eplerenone, spironolactone, amlodipine and levosimendan.
After contacting the extrudate cores with the medicinal agent, the extrudate cores are coated with at least one layer of fat. The coating is carried out at a temperature below 40° C, thereby integrating the active principle into a cold-applied fat or wax system to produce a nutritional and medicinal oral composition.
Claims Coverage
The patent excerpt includes two independent method claims. Both claims share the same central inventive construct: cold coating of complete feed extrudate cores with fat layers that carry a medicinal agent provided as non-encapsulated microparticles preconditioned as an oily solution/suspension or as waxy granules. The independent claims therefore cover two closely related implementation variants distinguished by how the fat composition is defined and obtained.
Cold fat coating of complete feed extrudate cores with a non-encapsulated medicated active principle
Supplying cores of complete feed extrudate; providing a medicinal agent as at least one active principle in the form of non-encapsulated microparticles preconditioned as a solution or a suspension of the active principle in an oily liquid, or preconditioned in the form of waxy granules; bringing the cores into contact with the medicinal agent; and coating the extrudate cores with at least one layer of fat at a temperature below 40° C.
Fat composition obtained containing the medicinal agent and cold coating with that fat composition
Supplying cores of complete feed extrudate; providing a medicinal agent as at least one active principle in the form of non-encapsulated microparticles preconditioned as a solution or a suspension of the active principle in an oily liquid, or preconditioned in the form of waxy granules; obtaining a fat composition comprising the medicinal agent; and coating the extrudate cores with at least one layer of the fat composition comprising the active principle at a temperature below 40° C.
Across both independent claims, the protected concept is cold-applied coating of extruded complete-feed cores with fat layers that carry a medicinal agent formulated as non-encapsulated microparticles preconditioned either as an oily solution/suspension or as waxy granules, with the processing temperature constrained to below 40° C.
Stated Advantages
Provides a nutritional and medicinal oral composition for veterinary use using cold application (temperature below 40° C) of fat layers carrying the medicinal agent.
Allows use of medicinal agents formulated as non-encapsulated microparticles preconditioned as oily solutions/suspensions or waxy granules rather than microencapsulation, as reflected in the excerpted description.
Enables improved stability of the active principle under conditions described in the excerpted description (stability determined by HPLC under various temperature/RH conditions).
Provides controlled/prolonged release and improved palatability/compliance, as stated in the excerpted description.
Documented Applications
Veterinary use as a nutritional and medicinal oral composition based on extruded complete-feed extrudate cores coated with fat layers carrying the medicinal agent.
Use for chronic disorders and/or renal insufficiency, as reflected in the excerpted description of benazepril use for renal insufficiency.
Palatability evaluation in cats, as reflected in the excerpted description.
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