System and method for affecting intestinal microbial flora
Inventors
Belhe, Kedar R. • Stangenes, Todd
Assignees
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Publication Number
US-10159699-B2
Publication Date
2018-12-25
Expiration Date
Abstract
Described is a system for affecting intestinal microbial flora. The system includes an intestinal sleeve that is implanted in a patient and bypasses a section of the intestine; and probiotics, prebiotics or pharmacologic therapy used in combination with the intestinal sleeve. Also described are related methods.
Core Innovation
The invention provides an endoscopically placeable and removable intestinal sleeve configured to bypass a section of intestine by preventing nutrients from contacting a lining of the intestine along a treatment length. By preventing nutrient contact along the treatment length, the invention reduces an initial microbial population along the treatment length without the use of antibiotics.
The intestinal sleeve is impregnated or coated with a probiotic therapy so that the probiotic therapy is deliverable at least to the treatment length of the intestine during implantation and after the intestinal sleeve is removed. The probiotic therapy promotes beneficial intestinal microbial flora at least along the treatment length while the intestinal sleeve is implanted and after it is removed.
The disclosure further describes implantation with anchoring at the pyloric junction. An anchoring element is described, including a Nitinol anchoring element with an optional biocompatible polymer or fabric covering, with embodiments including two flanges positioned respectively on the intestinal side and the stomach side.
Claims Coverage
The independent claim recites a system for treating obesity and diabetes using a removable intestinal sleeve that alters nutrient exposure and delivers probiotic therapy, with refinements for anchoring location, flanges, Nitinol, and a biocompatible polymer or fabric covering.
Removable intestinal sleeve preventing nutrient contact along a treatment length without antibiotics
A removable intestinal sleeve configured to be implanted along a treatment length of an intestine to prevent nutrients from contacting a lining along the treatment length, such that an initial microbial population along the treatment length is reduced without the use of antibiotics.
Probiotic therapy deliverable via an impregnated or coated sleeve during implantation and after removal
The intestinal sleeve is impregnated or coated with a probiotic therapy so that the probiotic therapy is deliverable at least to the treatment length while the intestinal sleeve is implanted and after the intestinal sleeve is removed, to promote beneficial intestinal microbial flora at least along the treatment length.
Anchoring at the pyloric junction
An anchoring element attached to the sleeve configured to anchor the sleeve at a patient's pyloric junction.
Two-flange anchoring across intestinal and stomach sides
An anchoring element with two flanges positioned respectively on the intestinal side and the stomach side of a patient when implanted.
Nitinol anchoring element
The anchoring element made from Nitinol.
Biocompatible polymer or fabric covering for the anchoring element
The anchoring element includes a covering made from a biocompatible polymer or fabric.
The claim coverage centers on a removable intestinal sleeve that prevents nutrients from contacting intestinal lining to reduce an initial microbial population without antibiotics, while the sleeve is impregnated or coated with probiotic therapy to promote beneficial intestinal microbial flora during implantation and after removal; the refinements specify pyloric junction anchoring, flanges, Nitinol construction, and an optional biocompatible polymer or fabric covering.
Stated Advantages
Reduces an initial microbial population along the treatment length without the use of antibiotics.
Promotes beneficial intestinal microbial flora at least along the treatment length of the intestine during implantation and after removal.
Treats obesity and diabetes.
Documented Applications
Treating obesity and diabetes using the removable intestinal sleeve that prevents nutrients from contacting intestinal lining along a treatment length while reducing an initial microbial population without antibiotics and delivering probiotic therapy to promote beneficial intestinal microbial flora.
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