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Publication Number
US-10149968-B2
Publication Date
2018-12-11
Expiration Date
Abstract
A method for treating a subject diagnosed with a cancer or other disorder comprising a hyperproliferative tissue is described herein. The method includes localized delivery of a material which contains a therapeutically effective agent and/or moiety. The localized delivery of the agent is achieved using a catheter-based delivery system and an implant. An implant can include a support component, a cover component, and a valve component. The valve component can be operable to permit flow through the implant. The implant can be delivered on a catheter, with one of the ends of the implant being selectively expanded to permit temporary occlusion of a vessel while delivering a material through the valve component to a downstream target region. The other end of the implant can thereafter be released such that the implant occludes the vessel, or the implant can be removed from the vessel entirely.
Core Innovation
A method and catheter-assisted system for treating a subject diagnosed with a cancer by advancing an implant to a target region of a body lumen near or containing the cancer. The implant has first and second sections engaged with a catheter at respective engagement points, and the implant is released and deployed to interact with the lumen wall at the target region.
The invention permits the implant first section to expand against a lumen wall at the target region such that the lumen becomes at least substantially occluded. While the first section is expanded to achieve at least substantial occlusion, therapeutic material is injected through a portion of the implant to treat the cancer.
The catheter-assisted delivery incorporates valve component structures and flow control concepts that permit outflow while restricting backflow, including selectively expanded portions that temporarily occlude a vessel to concentrate or localize delivery. Designs described include flaps and mesh-type one-way valve structures, supporting secondary procedures such as re-opening/unblocking for additional delivery or adding a second implant, including dual-implant deployment strategies to shield unintended branches.
Claims Coverage
The independent claim coverage centers on a catheter-advanced, two-section implant that is selectively expanded to substantially occlude a lumen at a cancer target region while therapeutic material is injected through the implant. The inventive features are captured across one explicitly provided independent claim and its dependent refinements.
Two-section catheter-advanced implant releasing and target occlusion
Advancing an implant to a target region of a body lumen near or containing the cancer, the implant having first and second sections engaged with a catheter at respective engagement points; releasing the implant first section from engagement with the catheter at the first engagement point; and permitting the implant first section to expand against a lumen wall at the target region such that the lumen becomes at least substantially occluded.
Injection while maintaining unexpanded catheter engagement
Injecting a therapeutic material through a portion of the implant while the implant second section remains unexpanded and engaged with the catheter, wherein the material is effective to treat the cancer.
Downstream blocking implant for occluding flow beyond the target
Prior to releasing the implant first section, releasing a blocking implant into contact against the lumen wall downstream of the target region such that the blocking implant occludes flow through the lumen beyond the target region.
Therapeutic material selected from named agent categories
Selecting the therapeutic material from nanoparticle, a radioembolic composition, a blood substitute comprising oxygen, a photothermal agent, or a chemotherapeutic effective to treat the cancer.
Gold or gold-iron oxide alloy nanoparticle for therapeutic material
Using the nanoparticle as a gold nanoparticle or a gold-iron oxide alloy nanoparticle effective to treat the cancer.
Catheter optical fiber emitting infrared light
Providing the catheter with an optical fiber extending from a proximal to a distal end, wherein the optical fiber can emit infrared light from the distal end of the catheter.
Optional x-irradiation or gamma-irradiation via catheter or externally
Administering x-irradiation or gamma-irradiation externally or internally through the catheter to the target region.
Across the independent claim and its provided dependents, the core claimed coverage combines a two-section implant advanced and engaged with a catheter, selective expansion of a first section to at least substantially occlude the lumen at the target region, and injection of therapeutic material through the implant while the second section remains unexpanded and catheter-engaged. The dependents further narrow the therapeutic material to named categories, add an optical-fiber infrared emitting catheter feature, provide an optional x- or gamma-irradiation delivery option, and optionally introduce a downstream blocking implant to occlude flow beyond the target region.
Stated Advantages
Temporarily occludes the lumen at the target region (at least substantially occluded) to enable localized treatment delivery.
Enables injecting a therapeutic material effective to treat the cancer while maintaining catheter engagement of the unexpanded implant section.
Provides downstream flow occlusion beyond the target region using a blocking implant.
Supports optional radiotherapy (x-irradiation or gamma-irradiation) externally or internally through the catheter.
Documented Applications
Treating a subject diagnosed with a cancer by catheter-assisted implant deployment to a target region of a body lumen near or containing the cancer.
Delivering radiosensitizers, oxygen-containing blood substitutes, radioembolic particles (including Y-90 microspheres), and photothermal agents (including gold and gold-iron oxide alloy nanoparticles) as localized therapeutic materials during cancer treatment.
Using optical-fiber infrared emission via the catheter to deliver photothermal effects during cancer treatment.
Applying optional x-irradiation or gamma-irradiation to the target region externally or internally through the catheter as part of cancer treatment.
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