Transpyloric anchoring
Inventors
Chamorro, Andres • Levine, Andy H. • Melanson, David A. • Maxwell, Barry • Gambale, Richard A.
Assignees
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Publication Number
US-10130502-B2
Publication Date
2018-11-20
Expiration Date
Abstract
A gastrointestinal implant device (2800) comprises a planar proximal element (220) configured to reside in a stomach to resist distal migration, a distal element (222) configured to reside in an intestine to resist proximal migration and one or more tethers (224) coupling the planar proximal element to the distal element.
Core Innovation
The disclosed invention relates to a gastrointestinal device that includes a conformable, collapsible sleeve through which chyme can pass from a proximal end to a distal end. The device further includes a transpyloric anchor having a wave anchor and a proximal element, and the wave anchor is connected to the proximal portion of the sleeve and is configured to form a seal against the duodenal wall while resisting movement associated with implantation.
The proximal element is configured to reside in an antrum of a stomach to resist distal migration across a pyloric sphincter. The invention specifies an implantation-dependent sizing relationship in which a first dimension of the proximal element is larger than the diameter of the pylorus of the stomach, while a second dimension of the proximal element is smaller than the diameter of the pylorus, the second dimension being orthogonal to the first dimension.
In one described configuration, the sleeve remains collapsible to enable endoscopic delivery and implanted function allowing chyme passage. Additional embodiments described in the document include a distal intestinal element and optional wave anchor features, together with one or more tethers coupling the proximal and distal elements to manage opposing proximal and distal migration.
Claims Coverage
The claims coverage identifies 4 inventive features.
Conformable collapsible sleeve permitting chyme passage
A conformable, collapsible sleeve through which chyme can pass from a proximal end of the sleeve to a distal end of the sleeve.
Transpyloric anchor with wave anchor sealing against duodenal wall
A transpyloric anchor comprising a wave anchor and a proximal element, wherein the wave anchor is connected to the proximal portion of the sleeve and is configured to form a seal against the duodenal wall.
Proximal element in stomach antrum resisting distal migration across pylorus
The proximal element is configured to reside in an antrum of a stomach and resist distal migration across a pyloric sphincter.
Orthogonal proximal element dimensions sized relative to pylorus diameter
When implanted in a patient, a first dimension of the proximal element is larger than the diameter of the pylorus of the stomach and a second dimension of the proximal element is smaller than the diameter of the pylorus, wherein the second dimension is orthogonal to the first dimension.
The inventive features combine a collapsible sleeve, a transpyloric anchor with a wave anchor, a proximal element positioned in the stomach antrum to resist distal migration, and orthogonal sizing relative to the pylorus diameter.
Stated Advantages
Resisting movement associated with implantation.
Resist distal migration across a pyloric sphincter.
Endoscopic delivery and implanted function allowing chyme passage.
Atraumatic/low side-effect intent by avoiding proximal stomach seal and tissue-penetrating features.
Documented Applications
A gastrointestinal device for chyme passage from a proximal end to a distal end.
Endoscopic delivery.
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