Dry composition comprising an extrusion enhancer

Inventors

Larsen, Kristian

Assignees

Ferrosan Medical Devices AS

Abstract

Disclosed is a dry composition comprising one or more polyols, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste reconstitutes spontaneously upon addition of the liquid; hence no mechanical mixing is required for said paste to form. The composition may further comprise an extrusion enhancer, such as albumin. Also disclosed are methods of preparing said dry composition, a paste obtained from said dry composition and uses of said dry composition or paste for medical and surgical purposes.

Core Innovation

The invention provides a dry haemostasis and wound healing composition comprising a cross-linked biocompatible polymer in powder form, one or more polyols, and an extrusion enhancer selected from albumin, phosphatidylcholine, phosphatidylserine, lecithin or soy bean oil. The dry composition further comprises an aqueous medium used during preparation to obtain a paste before drying.

The composition is prepared by providing the cross-linked biocompatible polymer powder, the one or more polyols, the extrusion enhancer and the aqueous medium, mixing them to obtain a paste, and freeze-drying the paste. The dry composition comprises from about 10% w/w to about 60% w/w of one or more polyols selected from sugar alcohols and sugars.

Upon addition of an aqueous medium, the dry composition spontaneously reconstitutes to form a paste without mechanical mixing. The partial content further discloses that reconstitution can be fast and that bioactive agents such as thrombin can be included with retained activity after freeze-drying and reconstitution.

Claims Coverage

The independent claim coverage centers on a single method for preparing a dry haemostasis and wound healing composition, with the core claim requiring freeze-drying of a paste made from a cross-linked biocompatible polymer, polyols, an extrusion enhancer, and an aqueous medium; the resulting dry composition contains about 10% w/w to about 60% w/w polyols and reconstitutes without mechanical mixing. No additional independent claims are explicitly provided in the supplied partial content.

Overall, the claim coverage requires a freeze-dried dry haemostasis and wound healing composition based on a cross-linked biocompatible polymer powder and specified polyols, with a selected extrusion enhancer, and spontaneous reconstitution into a paste without mechanical mixing.

Stated Advantages

Documented Applications