Wound dressings, methods and apparatus for making same and storage and use thereof
Inventors
Assignees
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Publication Number
US-10111979-B2
Publication Date
2018-10-30
Expiration Date
Abstract
Provided is a wound dressing prepared from whole blood that is clotted ex vivo to form a sheet of clotted blood that is applied onto the skin over a sight of skin injury.
Core Innovation
The invention relates to wound dressings that include clotted whole blood. Sterile whole-blood clot sheets are prepared ex vivo from withdrawn venous whole blood that is mixed with a coagulation initiator and allowed to clot in a location physically separated from the wound. The resulting sterile whole-blood clot is combined with a support matrix to form a sterile wound dressing.
The document addresses dressing wounds with clotted whole blood prepared without clotting at the wound site. It describes forming clotted whole-blood sheet dressings by spreading venous whole blood with anticoagulant and/or anticoagulant inhibitors, initiating coagulation ex vivo, and embedding or adhering support structures such as mesh or gauze.
It further describes maintaining sterility and enabling different application modes, including wet or dry application, as well as providing kits and apparatus for forming sheets, including vacuum-assisted clotting receptacles or plates and concurrent multi-sheet production.
Claims Coverage
The partial content provides two independent claims. Both focus on dressing a wound using a sterile whole-blood clot formed ex vivo and combined with a support matrix, with the additional requirement that the dressing remains in place for at least two days.
Withdrawing whole blood and clotting ex vivo to obtain a sterile whole-blood clot
Withdrawing a volume of whole blood by sterile withdrawal of venous blood from a subject; mixing the volume of whole blood with a coagulation initiator; allowing said whole blood to clot at a location physically separated from the wound to obtain a sterile whole-blood clot.
Combining the sterile whole-blood clot with a support matrix and applying to the wound
Combining said whole-blood clot with a support matrix to form a sterile wound dressing comprising clotted whole blood and the support matrix; applying said sterile wound dressing onto the wound, and leaving said sterile wound dressing in place for at least two days.
Clotting in a receptacle or tray and transferring the clot onto the wound
Withdrawing a volume of whole blood by sterile withdrawal of venous blood from a subject; mixing the volume of whole blood with a coagulation initiator; introducing the volume of whole blood to a receptacle or tray; allowing the volume of whole blood to clot to thereby obtain a sterile whole-blood clot; transferring said whole blood clot onto the wound.
Applying a support matrix on the wound clot to form a sterile dressing and leaving it in place
Applying a support matrix onto the whole blood clot when on said wound, to form a sterile wound dressing comprising clotted whole blood and the support matrix; and leaving said sterile wound dressing in place for at least two days.
Across the independent claims, the core coverage is the creation of a sterile whole-blood clot at a location physically separated from the wound, followed by combining or applying that clot with a support matrix to form a sterile wound dressing, and leaving the dressing in place for at least two days.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Wound dressing of burns and chronic ulcers, including pressure ulcers, venous ulcers, and skin tears.
Human wound results are described for 7 wounds, with reported healing outcomes and reduced need for dressing changes.
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