Implantable sensor
Inventors
DELBEKE, Danae • Baets, Roeland • Bogaerts, Wim • RYCKEBOER, Eva Maria Paula
Assignees
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Publication Number
US-10105081-B2
Publication Date
2018-10-23
Expiration Date
Abstract
A sensor for sensing a substance such as for example glucose. The sensor is implantable in the body of a living creature. The sensor has a photonic integrated circuit, e.g. silicon-photonics integrated circuit, for spectrally processing radiation interacting with the sample. A continuous monitoring system can also include such a sensor.
Core Innovation
The invention describes an implantable single-chip optical spectrometric sensor for sensing glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate in tissue or bodily fluids. The sensor includes an integrated radiation source that couples radiation generated by the source into a photonics integrated circuit for irradiating the tissue or bodily fluids having at least one of the specified substances. The integrated radiation source and the photonics integrated circuit form an integrated spectrometer for spectrally sensing absorption or reflection bands.
The photonics integrated circuit spectrally processes the radiation interacting with the glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate. The photonics integrated circuit comprises at least an integrated optical waveguide, an optical demultiplexer and an integrated detection element. The integrated optical waveguide receives radiation from the integrated radiation source and sends the radiation to the demultiplexer, where the optical demultiplexer is configured for spectrally processing the radiation.
The integrated detection element detects different absorption or reflection bands of the glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate from the spectrally processed radiation to sense the substances. The sensor is configured to be implantable in the body of a living creature or an object, and it is configured for sensing in tissue or bodily fluids. The described approach supports reagent-free operation and biocompatible transparent packaging to reduce biofouling in continuous monitoring contexts.
Claims Coverage
The document’s independent claim is clm-00001. It contains a core set of inventive features totaling an integrated spectrometer architecture for implantable spectrally resolved sensing of specified substances.
Integrated radiation source coupled into a photonics integrated circuit forming an integrated spectrometer
An integrated radiation source configured for coupling radiation into a photonics integrated circuit, wherein the radiation source and the photonics integrated circuit form an integrated spectrometer for irradiating tissue or bodily fluids having at least one of glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate.
Photonics integrated circuit with integrated optical waveguide, optical demultiplexer, and integrated detection element
A photonics integrated circuit configured to spectrally process radiation interacting with the glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate, the photonics integrated circuit comprising at least an integrated optical waveguide, an optical demultiplexer and a detection element.
Spectrally processed radiation detection of absorption or reflection bands
An integrated optical waveguide configured to receive radiation from the integrated radiation source and send the radiation to the demultiplexer, wherein the optical demultiplexer spectrally processes the radiation and the integrated detection element detects different absorption or reflection bands of the substances from the spectrally processed radiation to sense the glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate.
Implantable placement for sensing in tissue or bodily fluids
A sensor configured to be implantable in the body of a living creature or an object and configured for sensing in tissue or bodily fluids using the integrated spectrometer architecture to sense glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate.
Across the independent claim, the main inventive coverage is the integrated spectrometer formed by an integrated radiation source coupled into a photonics integrated circuit that includes an integrated optical waveguide, optical demultiplexer, and integrated detection element to detect different absorption or reflection bands for implantable sensing of the specified substances in tissue or bodily fluids.
Stated Advantages
Reagent-free operation for continuous monitoring.
Biocompatible transparent packaging to reduce biofouling.
Documented Applications
Continuous monitoring using an implantable sensor with wireless data transmission and inductive power.
Closed-loop drug delivery for insulin delivery.
Non-living platform sensing in bioreactors.
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