Real-time monitoring and control of physical and arousal status of individual organisms
Inventors
Berckmans, Daniel • Quanten, Stijn • Aerts, Jean-Marie
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-10076273-B2
Publication Date
2018-09-18
Expiration Date
Abstract
The present invention relates to methods and systems for monitoring and controlling the status of humans or animals, in particular relating to both the physical and the arousal status of an individual human or animal. These methods and systems rely on a dynamic and adaptive data-based on-line modelling technique wherein information on bioprocess inputs and outputs is measured in real-time and the model predicts an output based on the bioprocess input. The provided methods are particularly useful to monitor and/or control processes in which performance is important.
Core Innovation
The invention provides a computer-implemented method and related system for monitoring an estimation of an arousal component (HRPhAr) of a heart rate (HRtot) of an individual human or animal. The heart rate is treated as having a physical component (HRphys) and an arousal component (HRPhAr), with the arousal component obtained from a model that integrates measured, real-time information on bioprocess inputs and bioprocess outputs. The method uses at least one sensor for measuring real-time information on bioprocess inputs and/or bioprocess outputs and generates an on-line model by a dynamic and adaptive data-based on-line modelling technique.
At least one bioprocess input or output used as model input is a metabolism-related variable relating to metabolic energy and/or mobilized energy. The model outputs include an estimated component of the heart rate (HRmech) based on at least the metabolism-related variable, and the model is updated on-line by adapting parameters in real-time based on estimating and predicting model outputs and comparing the model outputs in real-time with measured bioprocess outputs. The measured heart rate (HRtot) is used to control the physical component (HRphys) or the arousal component (HRPhAr) by adapting at least one bioprocess input and/or an environmental variable changing a relationship between the bioprocess input and the bioprocess output.
The estimation of the arousal component (HRPhAr) is determined by subtracting, in real-time, components relating to basal metabolism (HRbmr) and heat balance (HRheat) from the difference between the real-time measured heart rate (HRtot) and a mechanical activity component (HRmech). The on-line modelling further expresses the real-time measured heart rate as a polynomial time-series model with a time delay (nk) and a dynamic error term (e(t)) describing the unknown variable attributed to the estimation of the arousal component.
Claims Coverage
The partial content provides three independent claims: a method claim, a system claim, and a computer program product claim. Each independent claim centers on an on-line, dynamic and adaptive modelling approach that decomposes measured heart rate using a metabolism-related variable and derives the arousal component via an unknown variable computed from basal metabolism, heat balance, and a mechanical activity component.
On-line adaptive estimation of an arousal component of heart rate using a metabolism-related variable
Uses at least one sensor for measuring real-time information on bioprocess inputs and/or outputs, generates an on-line model using a dynamic and adaptive data-based on-line modelling technique, uses a metabolism-related variable relating to metabolic energy and/or mobilized energy as model input, outputs an estimated heart-rate mechanical component (HRmech) based on at least the metabolism-related variable, measures real-time heart rate (HRtot), and updates model parameters on-line in real-time by adapting parameters based on estimating and predicting model outputs and comparing with measured bioprocess outputs.
Real-time decomposition of heart rate into basal metabolism, heat balance, and mechanical activity to form an unknown arousal variable
Determines a value for an unknown variable attributed to the estimation of the arousal component (HRPhAr) from a set of equations, where HRtot and the estimated component HRmech are known variables, and the estimation of HRPhAr is determined by subtracting in real-time the components relating to basal metabolism (HRbmr) and heat balance (HRheat) from the difference between HRtot and the mechanical activity component (HRmech), with the resulting difference being the value of the unknown variable attributed to HRPhAr.
Model expression with polynomials, time delay, and dynamic error term for on-line model updating
Generates the on-line model by expressing the real-time measured heart rate as a polynomial time-series model with a time delay (nk) and a dynamic error term (e(t)), in which B(q), F(q), C(q) and D(q) are polynomials including model parameters adapted for updating the model, q is a backward shift operator, and e(t) is a dynamic error term describing the unknown variable attributed to HRPhAr.
System for monitoring and prompting a status change based on estimated arousal component
Provides a system comprising at least one sensor for measuring real-time information on bioprocess inputs and outputs with at least one variable relating to metabolic energy and/or mobilized energy, a first processor configured to generate an estimated heart-rate mechanical component (HRmech) and to on-line adapt model parameters in real-time based on estimating and predicting model outputs and comparing with measured bioprocess outputs, and an output component that prompts a change in status by adapting at least one bioprocess input and/or an environmental variable changing a relationship between bioprocess input and bioprocess output, where HRPhAr is determined by subtracting basal metabolism (HRbmr) and heat balance (HRheat) from the difference between HRtot and HRmech.
Tangible computer program product for on-line modelling and subtractive arousal estimation
Provides a computer program product operable to cause data processing for use in a system, including software code for collecting and storing real-time information on bioprocess inputs and outputs with at least one input relating to metabolic energy and/or mobilized energy, software code for on-line modelling and generating an estimation of the heart-rate mechanical component (HRmech) based on the metabolism-related variable, and adapting the arousal component estimation (HRPhAr) by subtracting the estimated HRmech along with HRbmr and HRheat from the measured HRtot such that the resulting difference is a value of an unknown variable attributed to HRPhAr.
Across the independent claims, the coverage focuses on on-line dynamic and adaptive modelling using a metabolism-related variable, expressing HRtot via a polynomial model with time delay and a dynamic error term, and deriving an arousal component estimate (HRPhAr) via subtraction using basal metabolism and heat balance components together with the mechanical activity component.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?