Polymeric sorbent for removal of impurities from whole blood and blood products
Inventors
Chan, Phillip P. • Capponi, Vincent J. • Golobish, Thomas D. • Ali, Humayra Begum
Assignees
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Publication Number
US-10064406-B2
Publication Date
2018-09-04
Expiration Date
Abstract
The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.
Core Innovation
A storage container for storage and purification of blood, blood product or physiologic fluid prior to transfusion into a patient is provided, where the storage container is a compliant container suitable for storage and includes a purification device within the compliant container. The purification device contains a sorbent comprising hemocompatible material suitable for treating blood, blood product or physiologic fluid by increasing shelf life, maintaining freshness, and removing undesirable molecules from the blood, blood product or physiologic fluid.
The sorbent comprises cross-linked polymeric material derived from the reaction of a cross-linker with one or more specified polymerizable monomers, including divinylbenzene, styrene, ethylstyrene, acrylonitrile, and multiple acrylate and methacrylate monomers. The sorbent further comprises a hemocompatible surface that is chemically bound to the cross-linked polymeric material and is selected from specific hemocompatible materials including hydroxyethyl cellulose, hydroxypopyl cellulose, heparin, polyethylene glycol, poly(N-vinylpyrrolidinone), salts of poly(methacrylic acid) and salts of poly(acrylic acid), and copolymers of mixtures thereof.
The sorbent is contained within the purification device and is separated from the blood, blood product or physiologic fluid by a membrane that allows liquid comprising undesirable molecules to pass through the membrane and contact the sorbent. The membrane substantially excludes white blood cells, red blood cells and platelets from passing through the membrane and contacting the sorbent. The sorbent is supplied as slurry, suspension, dry powder, or other dry particulate and is non-immobilized within the purification device, and the storage container is a bag.
Claims Coverage
The partial content provides one independent claim (clm-00001) directed to a compliant blood storage container with an internal purification device using a hemocompatible sorbent separated by a membrane.
Compliant blood storage container with internal purification device
A compliant storage container suitable for storage of blood, blood products or physiologic fluids, where the storage container includes a purification device within the compliant container.
Hemocompatible cross-linked polymer sorbent for removal of undesirable molecules
A sorbent contained in the purification device comprising hemocompatible material performing at least one of increasing shelf life, maintaining freshness, and removing undesirable molecules from the blood, blood product or physiologic fluid, wherein the sorbent comprises cross-linked polymeric material derived from a cross-linker reaction with one or more specified polymerizable monomers.
Chemically bound hemocompatible surface on cross-linked polymeric sorbent
A sorbent having a hemocompatible surface comprising specified hemocompatible materials, where the hemocompatible surface is chemically bound to the cross-linked polymeric material.
Membrane permitting passage of undesirable-molecule liquid while excluding blood cells
A purification device structure where the sorbent is separated from the blood, blood product or physiologic fluid by a membrane that allows liquid comprising undesirable molecules to pass through the membrane and contact the sorbent, while the membrane substantially excludes white blood cells, red blood cells and platelets from passing through the membrane and contacting the sorbent.
Non-immobilized hemocompatible sorbent form and bag container
Wherein the hemocompatible material is supplied as slurry, suspension, dry powder or other dry particulate and is non-immobilized within the purification device, and wherein the storage container is a bag.
Across the single independent claim provided, the inventive coverage centers on a compliant bag-type blood storage container that incorporates an internal purification device using a hemocompatible sorbent built from cross-linked polymeric material with a chemically bound hemocompatible surface, with separation from the blood by a membrane that permits undesirable-molecule-containing liquid to reach the sorbent while excluding white blood cells, red blood cells, and platelets.
Stated Advantages
Increasing shelf life of the blood, blood product or physiologic fluid.
Maintaining freshness of new blood, blood product or physiologic fluid.
Removing undesirable molecules from the blood, blood product or physiologic fluid.
Documented Applications
Storage and purification of blood, blood product or physiologic fluid prior to transfusion into a patient using a compliant storage container that includes a purification device with hemocompatible sorbent separated by a membrane.
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