Electrical biosensor for detecting a substance in a bodily fluid, and method and system for same
Inventors
Assignees
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Publication Number
US-10060916-B2
Publication Date
2018-08-28
Expiration Date
Abstract
An electrical biosensor for use with a reader is provided and can include an electrical component configured such that the coupling of a targeted substance to a surface of the electrical component changes an electrical characteristic of the electrical component. A protein immobilization structure can be disposed on the surface and can include an array of functionalized structures for interacting with a substance in a sample of a bodily fluid. Each functionalized structure can include a protein capable of binding to a targeted chemical substance or substance in the sample whereby an electrical reading can be obtained by a reader to determine the concentration level of the targeted substance in the sample.
Core Innovation
The invention relates to an electrical biosensor for use with a reader to detect a concentration level of a substance in a sample of a bodily fluid. The electrical biosensor includes an electrical component having an electrical characteristic and a surface, wherein coupling of the substance to the surface changes the electrical characteristic of the electrical component. The electrical component includes first and second electrodes adapted to electrically couple to the reader so the reader obtains an electrical reading that is a function of the electrical characteristic.
A protein immobilization structure is disposed on the surface of the electrical component and includes a high-ba dielectric ALD layer, nanoparticles adhering to the high-ba dielectric ALD layer, and an array of functionalized structures interacting with the substance. Each functionalized structure includes a protein capable of binding to the substance and is bonded to one of the nanoparticles adhered to the high-ba dielectric ALD layer. With the protein immobilization structure and the coupling-induced electrical characteristic change, an electrical reading can be obtained by the reader to determine the concentration level of the substance in the sample.
The described system supports electrical biosensing in bodily fluids and, in example embodiments, can be configured with therapeutic drugs and/or biomarkers as the substance to be detected. The sensor package can include multiple electrical biosensors arranged on a disposable strip for use with the reader, and the sensing can be used to determine concentration level based on the reader-obtained electrical reading.
Claims Coverage
The provided independent claim covers an electrical biosensor used with a reader to measure a concentration level in bodily fluid by detecting an electrical reading that changes due to substance coupling to a sensor surface, with a specific protein immobilization structure using a high-ba dielectric ALD layer and adhered nanoparticles carrying an array of functionalized, protein-binding structures.
Electrical component with substance-coupling electrical characteristic change
The electrical biosensor includes an electrical component having an electrical characteristic and a surface, wherein the coupling of the substance to the surface changes the electrical characteristic of the electrical component, and the electrical component has first and second electrodes adapted to electrically couple to the reader for obtaining an electrical reading from the electrical component that is a function of the electrical characteristic.
Protein immobilization structure with high-ba dielectric ALD layer and adhered nanoparticles
A protein immobilization structure disposed on the surface of the electrical component includes a high-ba dielectric ALD layer, nanoparticles that adhere to the high-ba dielectric ALD layer, and an array of functionalized structures for interacting with the substance.
Functionalized structures with proteins bonded to nanoparticles
Each functionalized structure includes a protein capable of binding to the substance and is bonded to one of the nanoparticles that is adhered to the high-ba dielectric ALD layer, whereby an electrical reading can be obtained by the reader to determine the concentration level of the substance in the sample of the bodily fluid.
Overall, the claim set ties concentration determination to reader-obtained electrical readings caused by substance coupling to an electrical component surface, while specifying a protein immobilization structure that uses a high-ba dielectric ALD layer with adhered nanoparticles carrying an array of protein-binding functionalized structures.
Stated Advantages
Enables the reader to obtain an electrical reading to determine the concentration level of the substance in a sample of bodily fluid.
Documented Applications
Detecting a concentration level of a substance in a sample of bodily fluid using an electrical biosensor and a reader.
Using therapeutic drugs and/or biomarkers as the substance to be detected in bodily fluids.
Providing multiple electrical biosensors on a disposable strip for use with the reader.
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