Synergistic nutritional compositions and uses thereof
Inventors
Lambers, Teartse Tim • van Tol, Eric A. F.
Assignees
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Publication Number
US-10034937-B2
Publication Date
2018-07-31
Expiration Date
Abstract
Provided are nutritional compositions comprising a combination of a probiotic, dietary butyrate and/or a component for stimulating butyrate production in the human gut. Further disclosed are methods of accelerating tolerance to cow's milk allergy in a pediatric subject by providing said nutritional compositions to a target subject.
Core Innovation
The invention provides a nutritional composition for a pediatric subject, comprising per 100 Kcal specified amounts of a carbohydrate source, a protein source, and a fat source. The composition also includes a defined amount of Lactobacillus rhamnosus GG within a specified CFU range and dietary butyrate within a specified range.
A core aspect is combining viable Lactobacillus rhamnosus GG with dietary butyrate in pediatric nutritional compositions, including encapsulated or coated forms and multiple butyrate-related sources. The dietary butyrate may comprise butyrate salts and stereoisomeric or corresponding mixtures, and may include phenylalanine-butyramide (FBA) and other butyrate amides, salts, or esters.
Another core aspect is using a component that stimulates endogenous butyrate production together with prebiotics. In particular, a microbiota-stimulating component is described that comprises polydextrose (PDX) and galacto-oligosaccharides (GOS) as a PDX/GOS synbiotic combination.
The disclosed compositions are described in the context of dietary management of food allergy and accelerating tolerance to cow’s milk allergy (CMA). The invention addresses allergic sensitization and tolerance acquisition by providing synergistic nutritional compositions including dietary butyrate and probiotic L. rhamnosus GG.
Claims Coverage
The independent claims identified in the provided claim set are for a nutritional composition defined per 100 Kcal with specified macronutrient ranges, a defined Lactobacillus rhamnosus GG CFU range, and a dietary butyrate range. Inventive features are primarily expressed through the per-100-Kcal composition constraints and the selection of butyrate-related ingredients and/or components that stimulate endogenous butyrate production.
Per-100-Kcal nutritional composition with LGG and dietary butyrate range
A nutritional composition comprising per 100 Kcal between about 6 g and about 22 g of a carbohydrate source, between about 1 g and about 7 g of a protein source, between about 1×10^4 CFU to about 1.5×10^12 CFU of Lactobacillus rhamnosus GG, and between about 22 mg and 280 mg of dietary butyrate.
Endogenous butyrate production by a PDX/GOS component
A nutritional composition wherein the component for stimulating endogenous butyrate production comprises polydextrose and galacto-oligosaccharides.
Dietary butyrate identity by specified butyrate-related compounds and salts/forms
A nutritional composition wherein the dietary butyrate consists of one or more specified butyrate-related compounds and/or corresponding mixtures and pharmaceutically acceptable salts, including pure diastereoisomeric and enantiomeric forms or mixtures.
Across the independent-claim coverage provided, the main inventive thrust is a pediatric nutritional composition defined per 100 Kcal that combines Lactobacillus rhamnosus GG with dietary butyrate in defined ranges. Dependent inventive features further narrow the approach by adding a PDX/GOS component to stimulate endogenous butyrate production, and by specifying dietary butyrate to particular butyrate-related compounds, mixtures, salts, and stereoisomeric forms.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Dietary management of food allergy and accelerating tolerance to cow’s milk allergy (CMA).
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