Dose guides for injection syringe
Inventors
Wong, Vernon G. • Pham, Tan • White, William S. • Huang, Glenn T. • Hu, Mae W.
Assignees
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Publication Number
US-10022502-B2
Publication Date
2018-07-17
Expiration Date
Abstract
Devices that guide the accurate loading and dispensing of predetermined doses of fluid from injection syringes are disclosed.
Core Innovation
The invention relates to systems for delivering a small dose volume from an injection syringe. The system includes a syringe barrel defining a proximal end and a distal end, and a plunger rod slidably disposed within the syringe barrel. A dose-delivery guide is disposed around the plunger rod adjacent to the proximal end of the syringe barrel and is rigid along its height, such that it stops movement of the plunger rod into the syringe barrel at a first predetermined distance.
The system further includes a dose-loading guide having a grip portion and a collar portion connected to the grip portion. The grip portion facilitates positioning of the collar portion along the plunger rod during dose loading and facilitates removal of the collar portion after dose loading. The collar portion is rigid along its height and defines an opening that removably receives the dose-delivery guide during dose-loading, with the collar portion disposed around the dose-delivery guide to stop plunger movement at a second predetermined distance.
A difference between the first predetermined distance and the second predetermined distance defines the dose volume. The patent content also describes using a geometric dose-volume relationship V=πr^2h, including compensation for syringe proximal depression, and proposes a dual spacer and guide system in which the dose-loading and dose-delivery components cooperate to control plunger travel and improve loading/delivery accuracy.
Claims Coverage
Two independent claims are identified. Both claims define rigid dose-delivery and dose-loading guides that stop plunger rod movement at first and second predetermined distances, where the difference between the distances defines a dose volume. The claims also recite structural arrangements for disposing the guides around the plunger rod adjacent to the proximal end of the syringe barrel and for using a collar opening during dose loading.
Rigid dose-delivery guide stopping plunger at a first predetermined distance
A dose-delivery guide disposed at least partially around the plunger rod adjacent to the proximal end of the syringe barrel, rigid along its height, and configured to stop movement of the plunger rod into the syringe barrel at a first predetermined distance defined between the proximal end of the syringe barrel and the distal end of the plunger rod.
Removable rigid dose-loading collar defines an opening for the dose-delivery guide and stops plunger at a second predetermined distance
A dose-loading guide comprising a grip portion and a collar portion connected to the grip portion, where the grip portion facilitates positioning of the collar portion along the plunger rod during dose loading and facilitates removal of the collar portion after dose loading, the collar portion is rigid along its height, defines an opening that removably receives the dose-delivery guide during dose-loading, is disposed around the dose-delivery guide, and stops movement of the plunger rod into the syringe barrel at a second predetermined distance defined between the proximal end of the syringe barrel and the distal end of the plunger rod.
Dose volume defined by difference between first and second predetermined distances
A difference between the first predetermined distance and the second predetermined distance defines a dose volume delivered from an injection syringe.
First predetermined distance with dose-delivery guide disposed around the plunger rod and removable loading collar around the dose-delivery guide
The dose-delivery guide is configured such that when disposed around the plunger rod the dose-delivery guide stops movement of the plunger rod into the syringe barrel at a first predetermined distance, and the collar portion configured such that when disposed around the dose-delivery guide the collar portion stops movement of the plunger rod into the syringe barrel at a second predetermined distance, wherein the difference between the first predetermined distance and the second predetermined distance defines a dose volume.
The independent claims cover delivering a small dose volume by using rigid guide structures that control plunger travel. In both claims, a dose-delivery guide stops at a first predetermined distance and a removable rigid dose-loading collar stops at a second predetermined distance, with the dose volume defined by the difference between those distances. Claim 1 further recites structural detail regarding the collar opening removably receiving the dose-delivery guide during dose loading, and the associated guide arrangement.
Stated Advantages
Improved loading/delivery accuracy using the guides.
Documented Applications
Delivery of small dose volumes including pharmaceutical/biologic contexts such as insulin and ranibizumab (Lucentis®), bevacizumab (Avastin®), and VEGF Trap-Eye.
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