Chamber for encapsulating secreting cells
Inventors
Bou Aoun, Richard • Sigrist, Severine • Sproll, Stefan
Assignees
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Publication Number
US-10022404-B2
Publication Date
2018-07-17
Expiration Date
Abstract
The invention relates to an encapsulating chamber for secreting cells, comprising a closed shell made of a semi-permeable membrane, said membrane comprising at least one layer of porous biocompatible polymer, and one layer of non-woven biocompatible polymer.
Core Innovation
The invention relates to a chamber for encapsulating secreting cells producing at least one substance of therapeutic interest. The chamber comprises a closed shell made of a semi-permeable membrane that delimits a space capable of containing the secreting cells and enables selective exchange while keeping the secreting cells within the enclosed space.
The semi-permeable membrane includes a layer of biocompatible non-woven polymer located between two layers of porous biocompatible polymers. The porous biocompatible polymer layers provide a diffusion pathway, while the non-woven biocompatible polymer layer is positioned between them as part of the membrane structure.
The membrane composition is used to maintain selective diffusion consistent with excluding immune system components such as antibodies (IgG) and cells, while improving mechanical resistance for implantable use. The membrane can also be hydrophilized by surface modification such as polar sites or plasma treatment, can be covered with hydrophilic polymers, and can include biologically active molecules and support structures for the chamber.
Claims Coverage
The document provides one independent claim covering an encapsulating chamber and a semi-permeable membrane architecture with a biocompatible non-woven polymer layer between two porous biocompatible polymer layers. The dependent claims refine this independent claim with additional membrane structure and optional features, including quantitative pore characteristics, hydrophilization, material selections, and chamber structural elements.
Closed-shell encapsulating chamber with semi-permeable membrane for secreting cells
A chamber for encapsulating secreting cells producing at least one substance of therapeutic interest, comprising a closed shell made of a semi-permeable membrane delimiting a space capable of containing the secreting cells producing at least one substance of therapeutic interest.
Non-woven polymer between two porous biocompatible polymer layers
The semi-permeable membrane comprises a layer of biocompatible non-woven polymer located between two layers of porous biocompatible polymers.
The claim coverage centers on an encapsulating chamber whose closed shell uses a semi-permeable membrane that includes a biocompatible non-woven polymer layer positioned between two porous biocompatible polymer layers, forming a membrane architecture intended to control selective diffusion while containing secreting cells.
Stated Advantages
Improved mechanical resistance for implantable bioartificial organs.
Reduced fibrosis and cell infiltration after implantation.
Increased vascularization after implantation.
Improved diffusion/permeability behavior, including blocking of immune system antibodies (IgG).
Documented Applications
Implantable bioartificial organs.
A bioartificial pancreas (islets of Langerhans) used for encapsulating secreting cells producing at least one therapeutic substance.
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