Biochip including side emitting-type light-emitting device and fabrication method thereof
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Publication Number
US-10018562-B2
Publication Date
2018-07-10
Expiration Date
Abstract
The present disclosure a biochip including a side emitting-type light-emitting device, in which the bio-chip includes: a light-emitting device for emitting light from a fluorescent material; reflective layers provided over and under the light-emitting device so as to emit light from the sides of the light-emitting device; and reaction regions formed by etching of flanking regions of the light-emitting device. In the biochip, light emitted from the sides of the light-emitting device causes a biochemical reaction in the reaction regions. According to the present disclosure, light emitted from the light-emitting device moves only laterally without being transferred to the top or bottom of the bio-layer, and is transferred to the reaction regions formed by etching of flanking regions of the light-emitting device, so that a biochemical reaction in the reaction regions can be more efficiently performed.
Core Innovation
The invention relates to a biochip architecture in which a bio-layer includes a plurality of reaction regions and a plurality of side-emitting-type light-emitting devices arranged adjacent to the reaction regions. Each light-emitting device includes a light-emitting region, a first reflective layer below the light-emitting region, and a second reflective layer above the light-emitting region, and the first reflective layer and the second reflective layer function as blocking layers to prevent light from the light-emitting region from being emitted from a top surface or a bottom surface of the bio-layer.
Because top and bottom emission is blocked, light from the light-emitting region is transmitted laterally within the bio-layer. The reaction regions receive light transmitted from the plurality of light-emitting devices, including reception through respective sides of at least two adjacent light-emitting devices, and the reference sample is uniformly spread in each reaction region between a top of the bio-layer, a bottom of the bio-layer, and the respective sides of the at least two light-emitting devices.
The biochip includes an image sensor layer formed under the bio-layer and having a plurality of photodetectors configured to detect light from at least one of the reaction regions. The document further describes an optional filter layer positioned between the bio-layer and the image sensor layer to suppress unwanted light reaching the photodetectors, and fabrication by forming a light-emitting device layer with a first reflective layer and a second reflective layer around a light-emitting region and then etching flanking regions to form the reaction regions.
Claims Coverage
The independent claim covers four inventive features: a bio-layer with side-emitting-type light-emitting devices and blocking layers, reaction regions receiving lateral light from adjacent devices, an image sensor layer with photodetectors under the bio-layer, and a reference sample uniformly spread in each reaction region.
Blocking layers for lateral light transmission in a bio-layer
A bio-layer with a plurality of light-emitting devices in which a first reflective layer below the light-emitting region and a second reflective layer above the light-emitting region function as blocking layers to prevent light from being emitted from a top surface or a bottom surface of the bio-layer such that light is transmitted laterally within the bio-layer.
Reaction regions receive lateral light from adjacent devices through respective sides
A plurality of reaction regions adjacent to the light-emitting devices such that light transmitted from the plurality of light-emitting devices is received by the reaction regions, wherein each reaction region receives light transmitted from at least two light-emitting devices through respective sides of the at least two light-emitting devices.
Image sensor layer detecting light from reaction regions
An image sensor layer formed under the bio-layer and having a plurality of photodetectors for detecting light from at least one of the plurality of reaction regions.
Uniformly spread reference sample in reaction regions
The reference sample is uniformly spread in each reaction region between a top of the bio-layer, a bottom of the bio-layer, and the respective sides of the at least two light-emitting devices.
The independent claim combines blocking of top and bottom emission, lateral transmission into reaction regions, detection by an under-lying image sensor layer, and uniform spreading of the reference sample relative to the reaction-region sides.
Stated Advantages
Prevents light from the light-emitting region from being emitted from a top surface or a bottom surface of the bio-layer, so light is transmitted laterally within the bio-layer.
Ensures light from at least two adjacent light-emitting devices is received by each reaction region through respective sides.
Enables detection of light from reaction regions using photodetectors formed in an image sensor layer under the bio-layer.
Documented Applications
Use as a biochip having reaction regions for a biochemical reaction between a reference sample and a target sample.
Use with an image sensor layer having photodetectors for detecting light from reaction regions.
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