Perimeter Knightworks
Perimeter develops and operates dynamic biosecurity infrastructure that provides continuous biothreat detection, risk characterization, and actionable response guidance for diverse operational environments. The company leverages advanced computational biology and artificial intelligence to deliver early warning and biological intelligence for decision-making and preparedness at community and national levels.
Industries
Nr. of Employees
medium (51-250)
Perimeter Knightworks
Products
BioThreat Radar
Perimeter’s BioThreat Radar is a “system of systems” built on its Canopy biosurveillance and biological intelligence platform. It combines strategically placed sampling nodes—such as airports, hospitals, military sites, agricultural facilities, and wastewater systems—with laboratory analysis, genomic sequencing, data integration, and expert interpretation to detect, characterize, and respond to biological threats. By converting biological samples and disparate surveillance feeds into actionable intelligence, BioThreat Radar helps public-health, biodefense, and national-security stakeholders distinguish baseline conditions from emerging anomalies and make faster, better-informed decisions.
Canopy
Perimeter’s Canopy is an interoperable biosurveillance and biological intelligence platform that serves as the operational backbone for Biothreat Radar programs. It sits on top of existing laboratory infrastructure and unifies sample registration, metadata, chain-of-custody tracking, laboratory workflows, quality control, genomic and diagnostic results, and downstream bioinformatic analysis. Canopy also integrates partner, environmental, epidemiological, and other surveillance data into a common operating picture, helping organizations standardize operations, improve traceability, and transform biological signals into decision-ready intelligence for early warning and response.
Data Feeds
Perimeter’s data feeds extend Canopy’s operational platform with complementary digital and physical surveillance signals, including open-source intelligence (OSINT), travel-hub risk, active outbreak monitoring, and sample-based detection data. OSINT feeds synthesize signals from official and unofficial public-health sources, news media, and outbreak reporting to identify and contextualize infectious-disease events; the Active Outbreaks feed organizes current events with geographic case and death information and evolving threat scores; and the Transit Hub feed provides relative risk metrics for infected passengers arriving at or departing from airports across the commercial air-transport network. These feeds can be combined with sampling data from Canopy nodes—such as aircraft, municipal, hospital, environmental, and human samples—to connect global context with local biological evidence and support a more complete, decision-ready picture of emerging threats.
BioThreat Radar
Perimeter’s BioThreat Radar is a “system of systems” built on its Canopy biosurveillance and biological intelligence platform. It combines strategically placed sampling nodes—such as airports, hospitals, military sites, agricultural facilities, and wastewater systems—with laboratory analysis, genomic sequencing, data integration, and expert interpretation to detect, characterize, and respond to biological threats. By converting biological samples and disparate surveillance feeds into actionable intelligence, BioThreat Radar helps public-health, biodefense, and national-security stakeholders distinguish baseline conditions from emerging anomalies and make faster, better-informed decisions.
Canopy
Perimeter’s Canopy is an interoperable biosurveillance and biological intelligence platform that serves as the operational backbone for Biothreat Radar programs. It sits on top of existing laboratory infrastructure and unifies sample registration, metadata, chain-of-custody tracking, laboratory workflows, quality control, genomic and diagnostic results, and downstream bioinformatic analysis. Canopy also integrates partner, environmental, epidemiological, and other surveillance data into a common operating picture, helping organizations standardize operations, improve traceability, and transform biological signals into decision-ready intelligence for early warning and response.
Data Feeds
Perimeter’s data feeds extend Canopy’s operational platform with complementary digital and physical surveillance signals, including open-source intelligence (OSINT), travel-hub risk, active outbreak monitoring, and sample-based detection data. OSINT feeds synthesize signals from official and unofficial public-health sources, news media, and outbreak reporting to identify and contextualize infectious-disease events; the Active Outbreaks feed organizes current events with geographic case and death information and evolving threat scores; and the Transit Hub feed provides relative risk metrics for infected passengers arriving at or departing from airports across the commercial air-transport network. These feeds can be combined with sampling data from Canopy nodes—such as aircraft, municipal, hospital, environmental, and human samples—to connect global context with local biological evidence and support a more complete, decision-ready picture of emerging threats.
Services
Perimeter’s lab enablement services help partner laboratories build sustainable capacity to operate biosurveillance programs using existing infrastructure. The work begins with readiness assessments covering instrumentation, staffing, workflows, expertise, and quality systems, followed by targeted support such as protocol transfer, equipment and procurement guidance, assay and method development, workflow optimization, hands-on training, quality assurance, and integration with local laboratory information systems. Perimeter can support wet-lab activities—including sample processing, PCR, and sequencing—as well as dry-lab bioinformatics, reporting, and technical reachback; the goal is to standardize and validate workflows while progressively enabling local teams to operate independently, with continued expert support for troubleshooting, specialized analysis, and surge response.
Perimeter’s digital analysis services convert laboratory and surveillance data into interpretable biological intelligence through integrated bioinformatics and epidemiological modeling. Its bioinformatics capabilities support high-throughput processing of PCR, targeted and metagenomic sequencing data; pathogen, lineage, and antimicrobial-resistance detection; variant calling; phylodynamic and phylogenetic analysis; mixed-sample deconvolution; anomaly review; and screening for potential genetic-engineering signatures. Perimeter’s epidemiology services complement these analyses with geospatial and temporal modeling, disease-spread and travel-risk assessment, signal triage, forecasting, threat scoring, and outbreak-impact analysis. Together, these tools and subject-matter expertise help characterize unusual signals, assess origins and transmission, prioritize surveillance and response actions, and deliver standardized reports and decision support through the Canopy and Command Hub environments.
Perimeter’s lab enablement services help partner laboratories build sustainable capacity to operate biosurveillance programs using existing infrastructure. The work begins with readiness assessments covering instrumentation, staffing, workflows, expertise, and quality systems, followed by targeted support such as protocol transfer, equipment and procurement guidance, assay and method development, workflow optimization, hands-on training, quality assurance, and integration with local laboratory information systems. Perimeter can support wet-lab activities—including sample processing, PCR, and sequencing—as well as dry-lab bioinformatics, reporting, and technical reachback; the goal is to standardize and validate workflows while progressively enabling local teams to operate independently, with continued expert support for troubleshooting, specialized analysis, and surge response.
Perimeter’s digital analysis services convert laboratory and surveillance data into interpretable biological intelligence through integrated bioinformatics and epidemiological modeling. Its bioinformatics capabilities support high-throughput processing of PCR, targeted and metagenomic sequencing data; pathogen, lineage, and antimicrobial-resistance detection; variant calling; phylodynamic and phylogenetic analysis; mixed-sample deconvolution; anomaly review; and screening for potential genetic-engineering signatures. Perimeter’s epidemiology services complement these analyses with geospatial and temporal modeling, disease-spread and travel-risk assessment, signal triage, forecasting, threat scoring, and outbreak-impact analysis. Together, these tools and subject-matter expertise help characterize unusual signals, assess origins and transmission, prioritize surveillance and response actions, and deliver standardized reports and decision support through the Canopy and Command Hub environments.
Expertise Areas
- Biosecurity infrastructure
- Biosurveillance
- Pathogen genomic surveillance
- Computational biology
Key Technologies
- Continuous sensing modalities
- AI-driven threat analysis
- Genomic sequencing
- Predictive modeling
Key People
Matt McKnight
CEO
Matt McKnight
CEO