TransTissue Technologies
TransTissue Technologies is a company focused on inventions and new methods for tissue regeneration, leading to novel Tissue Engineering products and platform technologies. It is a spin-off of Charité-Universitätsmedizin Berlin and is part of the BioTissue group. The company's mission is to establish regenerative medicine in daily clinical life by translating innovative research into medical products that meet GMP standards. The company emphasizes its commitment to research, development, and broad support of research and development activities in regenerative medicine.
Industries
Nr. of Employees
small (1-50)
TransTissue Technologies
Products
Autologous 3D chondrocyte graft for articular cartilage repair
A GMP-manufactured autologous three-dimensional chondrocyte graft intended to restore articular cartilage defects by implanting patient-derived expanded chondrocytes on a mechanically stable scaffold.
Autologous 3D jawbone graft
A GMP-manufactured autologous three-dimensional bone graft used to repair jawbone defects, based on expanded autologous progenitor cells combined with a 3D scaffold.
Cell-free implantable cartilage matrix for microfracture augmentation
A cell-free implantable matrix intended to recruit endogenous mesenchymal progenitor cells to cartilage defects and guide in situ regeneration as an adjunct to microfracture procedures; compliant with applicable CE requirements for clinical use in Europe.
Autologous 3D chondrocyte graft for articular cartilage repair
A GMP-manufactured autologous three-dimensional chondrocyte graft intended to restore articular cartilage defects by implanting patient-derived expanded chondrocytes on a mechanically stable scaffold.
Autologous 3D jawbone graft
A GMP-manufactured autologous three-dimensional bone graft used to repair jawbone defects, based on expanded autologous progenitor cells combined with a 3D scaffold.
Cell-free implantable cartilage matrix for microfracture augmentation
A cell-free implantable matrix intended to recruit endogenous mesenchymal progenitor cells to cartilage defects and guide in situ regeneration as an adjunct to microfracture procedures; compliant with applicable CE requirements for clinical use in Europe.
Services
Contract laboratory services for cell isolation, primary cell expansion, 3D cultures and scaffold-seeded constructs using human and animal cells.
RNA isolation, quantitative RT-PCR and microarray-based expression profiling for characterization of cells and tissues.
In vitro functional assays including differentiation, proliferation, toxicity, migration assays and disease-relevant 3D models for drug testing and screening.
Advisory services for GMP implementation, validation and compliance, plus support for clinical study design, documentation and monitoring for medical devices.
Design, fabrication and functionalization of polymer and hydrogel scaffolds, including lyophilized bioactive scaffolds and laser microstructuring to tailor architecture and growth-factor release profiles.
Contract laboratory services for cell isolation, primary cell expansion, 3D cultures and scaffold-seeded constructs using human and animal cells.
RNA isolation, quantitative RT-PCR and microarray-based expression profiling for characterization of cells and tissues.
In vitro functional assays including differentiation, proliferation, toxicity, migration assays and disease-relevant 3D models for drug testing and screening.
Advisory services for GMP implementation, validation and compliance, plus support for clinical study design, documentation and monitoring for medical devices.
Design, fabrication and functionalization of polymer and hydrogel scaffolds, including lyophilized bioactive scaffolds and laser microstructuring to tailor architecture and growth-factor release profiles.
Expertise Areas
- Tissue engineering
- Regenerative medicine
- Scaffold biomaterials and hydrogel systems
- Mesenchymal stem and progenitor cell biology
Key Technologies
- 3D cell culture and perfusion systems
- Polymer-hydrogel scaffold fabrication (including polymer-hyaluronan blends)
- Freeze-drying (lyophilization) of scaffolds for controlled growth factor release
- Photopolymerizable hydrogels and stereolithographic methods
News & Updates
Research article published in 2020 by Saghari Fard MR, Krueger JP, Stich S, Berger P, Kühl AA, Sittinger M, Hartwig T, Endres M.
Research article published in 2020 by Hondke S, Cabraja M, Krüger JP, Stich S, Hartwig T, Sittinger M, Endres M.
Research article published in 2022 by Saghari Fard MR, Krueger JP, Stich S, Berger P, Kühl AA, Sittinger M, Hartwig T, Endres M.
Research article published in 2019 by Krüger JP, Hondke S, Lau S, Endres M.
Research article published in 2020 by Saghari Fard MR, Krueger JP, Stich S, Berger P, Kühl AA, Sittinger M, Hartwig T, Endres M.
Research article published in 2020 by Hondke S, Cabraja M, Krüger JP, Stich S, Hartwig T, Sittinger M, Endres M.
Research article published in 2022 by Saghari Fard MR, Krueger JP, Stich S, Berger P, Kühl AA, Sittinger M, Hartwig T, Endres M.
Research article published in 2019 by Krüger JP, Hondke S, Lau S, Endres M.