Sudhin Biopharma Co.
Sudhin Biopharma Co. specializes in innovative bioprocessing devices and technologies, including BioSettlers and inclined settling bioreactors, for applications in cell culture clarification, harvesting, and cell therapy. Their mission is to develop scalable, efficient solutions for high cell density cultures and bioproduct recovery, supporting advanced biomanufacturing and cell therapy applications.
Industries
Nr. of Employees
small (1-50)
Sudhin Biopharma Co.
Denver, Colorado, United States, North America
Patents
Products
Inclined/compact settler — 75 mm series (≈250–2000 mL)
Clear polycarbonate compact settler variants with multiple heights, top and bottom port configurations, and optional programmable shaking clamp; internal volumes ~241 mL to ~1995 mL.
Inclined/compact settler — 150 mm series (≈3.5–5.0 L)
Intermediate‑scale settler variants with stainless steel stands, multiple peripheral ports and a central top port for clarified effluent; internal volumes ~3.5 L and ~5.0 L.
Inclined/compact settler — 300 mm series (≈18–24 L)
Larger diameter settlers available in transparent polycarbonate (~17.4 L) with separate stand or stainless steel (~23.8 L) with integral stand; increased cone counts and settling area for higher capacity.
Single‑use disposable compact settler (6" / ~3.8 L example)
Disposable plastic compact settler launched as a modular attachment to bioreactors for clarification and selective cell retention; initial available size example: 6" diameter, 18" height, ~3.8 L void volume.
Research‑grade recombinant proteins and growth factors (Pichia pastoris)
Small‑quantity supplies of animal component‑free recombinant proteins (examples listed: brazzein, human albumin, hFGF2, hEGF, hIGF1, IL‑2) produced in Pichia pastoris, intended for research use.
BioSettler 75-1500
A BioSettler with a cylindrical diameter of 75 mm, internal volume of 1458 mL, settling area of 1395 cm2, 44 cones, and total height of 494 mm, fabricated in clear polycarbonate for visual inspection during operation.
Inclined/compact settler — 75 mm series (≈250–2000 mL)
Clear polycarbonate compact settler variants with multiple heights, top and bottom port configurations, and optional programmable shaking clamp; internal volumes ~241 mL to ~1995 mL.
Inclined/compact settler — 150 mm series (≈3.5–5.0 L)
Intermediate‑scale settler variants with stainless steel stands, multiple peripheral ports and a central top port for clarified effluent; internal volumes ~3.5 L and ~5.0 L.
Inclined/compact settler — 300 mm series (≈18–24 L)
Larger diameter settlers available in transparent polycarbonate (~17.4 L) with separate stand or stainless steel (~23.8 L) with integral stand; increased cone counts and settling area for higher capacity.
Single‑use disposable compact settler (6" / ~3.8 L example)
Disposable plastic compact settler launched as a modular attachment to bioreactors for clarification and selective cell retention; initial available size example: 6" diameter, 18" height, ~3.8 L void volume.
Research‑grade recombinant proteins and growth factors (Pichia pastoris)
Small‑quantity supplies of animal component‑free recombinant proteins (examples listed: brazzein, human albumin, hFGF2, hEGF, hIGF1, IL‑2) produced in Pichia pastoris, intended for research use.
BioSettler 75-1500
A BioSettler with a cylindrical diameter of 75 mm, internal volume of 1458 mL, settling area of 1395 cm2, 44 cones, and total height of 494 mm, fabricated in clear polycarbonate for visual inspection during operation.
Services
Collaborative design and joint development of settler devices and process integration for customer‑specific clarification, perfusion retention, or cell therapy applications.
Fabrication and performance testing of single‑use settlers at multiple sizes as part of funded scale‑up projects and consortium collaborations.
Sale of compact/inclined settler devices in multiple sizes and related accessories (stands, haptic clamps, tubing/port configurations).
Manufacture and distribution of research‑grade recombinant proteins expressed in Pichia pastoris, supplied in small sample quantities.
Collaborative design and joint development of settler devices and process integration for customer‑specific clarification, perfusion retention, or cell therapy applications.
Fabrication and performance testing of single‑use settlers at multiple sizes as part of funded scale‑up projects and consortium collaborations.
Sale of compact/inclined settler devices in multiple sizes and related accessories (stands, haptic clamps, tubing/port configurations).
Manufacture and distribution of research‑grade recombinant proteins expressed in Pichia pastoris, supplied in small sample quantities.
Expertise Areas
- Perfusion bioprocessing and cell retention
- Primary clarification of culture harvests
- Cell therapy product concentration and handling
- Recombinant protein production in Pichia pastoris
Key Technologies
- Inclined/lamellar settler technology
- Compact cell settler design
- Single‑use plastic bioprocess devices
- Perfusion bioreactor integration
News & Updates
Dhinakar Kompala gave an oral presentation at the International Forum on Cell Manufacturing & Engineering in Berlin, Germany on the use of Sudhin BioSettlers to recycle organoids, such as IPSC clusters, from the bottom of BioSettlers back to the bioreactors while removing the single cells and spent media from the top of BioSettler.
Oct, 2023
Dhinakar Kompala presented an invited 20 minute webinar, as a part of the Good Food Institute's monthly collaborative seminar series in October, discussing novel applications of Sudhin Biopharma's Inclined Settling Bioreactor for manufacturing cultured meat and inviting collaborators from this growing industry.
Sept, 2023
Dhinakar Kompala has been invited to give an oral presentation on “Inclined Settling Bioreactor for manufacturing of cell and gene therapy products” at the ECI conference Single Use Technologies VI in Boston.
July, 2023
Sudhin Biopharma scientist demonstrate growth of CHO cells inside the newly developed Inclined Settling Bioreactor with single use disposable fluorescent dye sensors and thermocouple to measure the cell culture parameters of pH, D.O. and Temperature and automation and control system developed by Rockwell Automation.
April, 2023
Dhinakar Kompala presents an invited talk at the BioMADE member meeting in Minneapolis, discussing the novel applications of Sudhin BioSettlers to break oil-water emulsions generated during in situ product recovery in extractive fermentations.
Feb, 2023
Dhinakar Kompala presented an invited talk on “BioSettler technology and its evolution in to an Inclined Settling Bioreactor for growing cell and gene therapy products” at the Colorado Emerging Medical Device in-person meetup.
Dhinakar Kompala gave an oral presentation at the International Forum on Cell Manufacturing & Engineering in Berlin, Germany on the use of Sudhin BioSettlers to recycle organoids, such as IPSC clusters, from the bottom of BioSettlers back to the bioreactors while removing the single cells and spent media from the top of BioSettler.
Oct, 2023
Dhinakar Kompala presented an invited 20 minute webinar, as a part of the Good Food Institute's monthly collaborative seminar series in October, discussing novel applications of Sudhin Biopharma's Inclined Settling Bioreactor for manufacturing cultured meat and inviting collaborators from this growing industry.
Sept, 2023
Dhinakar Kompala has been invited to give an oral presentation on “Inclined Settling Bioreactor for manufacturing of cell and gene therapy products” at the ECI conference Single Use Technologies VI in Boston.
July, 2023
Sudhin Biopharma scientist demonstrate growth of CHO cells inside the newly developed Inclined Settling Bioreactor with single use disposable fluorescent dye sensors and thermocouple to measure the cell culture parameters of pH, D.O. and Temperature and automation and control system developed by Rockwell Automation.
April, 2023
Dhinakar Kompala presents an invited talk at the BioMADE member meeting in Minneapolis, discussing the novel applications of Sudhin BioSettlers to break oil-water emulsions generated during in situ product recovery in extractive fermentations.
Feb, 2023
Dhinakar Kompala presented an invited talk on “BioSettler technology and its evolution in to an Inclined Settling Bioreactor for growing cell and gene therapy products” at the Colorado Emerging Medical Device in-person meetup.