Silverback Therapeutics


ARS Pharmaceuticals is dedicated to developing patient-friendly, needle-free treatments for severe allergic reactions, including an investigational intranasal epinephrine spray called ARS-1, which aims to be a reliable, easy-to-use, and portable alternative to auto-injectors. The company focuses on innovative drug delivery technologies and aims to provide safer, more accessible emergency treatment options for allergy sufferers.

Industries

biopharma
biotechnology
health-care
medical
therapeutics

Nr. of Employees

small (1-50)


Products

Intranasal epinephrine nasal spray (needle-free)

A low-dose aqueous intranasal epinephrine formulation intended to provide rapid systemic absorption comparable to intramuscular injection for emergency treatment of severe allergic reactions; designed for needle-free, portable administration and developed with a mucosal absorption-enhancing excipient.


Services

Co-pay assistance and patient/caregiver support resources to facilitate access to therapy for qualifying patients.

Expertise Areas

  • Clinical trial management (PK/PD and crossover designs)
  • Intranasal drug formulation and mucosal delivery
  • Pharmacokinetics and pharmacodynamics assessment
  • Regulatory strategy and FDA engagement (IND/NDA, expedited pathways)
  • Show More (4)

Key Technologies

  • Intranasal drug delivery
  • Nasal/mucosal absorption enhancing excipients
  • Pharmacokinetic (PK) and pharmacodynamic (PD) analysis
  • Bioequivalence testing
  • Show More (3)

News & Updates

ARS Pharmaceuticals announced that the FDA has granted Fast Track Designation for ARS-1, an investigational intranasal epinephrine spray, to facilitate its development and review for treating severe allergic reactions.

The company secured $20 million Series C financing led by Deerfield Management to support the clinical development of ARS-1, a needle-free epinephrine spray for allergy-related anaphylaxis.

Results demonstrate rapid epinephrine absorption with an overall pharmacokinetic profile comparable to epinephrine injection in allergy-induced patients.

ARS Pharmaceuticals presented new data at AAAAI 2020 showing bioequivalent exposure and rapid absorption of Neffy™ (ARS-1) intranasal epinephrine in allergy patients.

The FDA granted Fast Track Designation to ARS-1, an intranasal epinephrine spray, to facilitate its development for treating severe allergic reactions.


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