Developing a point-of-care device to measure both CBC and CMP in minutes at high accuracy and lower cost.
#Diagnostics / Point-of-care testing
Platform delivers drugs at stable levels for up to 12 months from a single implant.
#Drug delivery / MedTech
Developed polymeric micelles (~15 nm) to penetrate tumor stroma and deliver payloads (targeting difficult tumors like pancreatic).
#Oncology / Drug delivery
Develops tunnel-boring technology to allow renewable projects to connect to the grid.
#CleanTech / Energy infrastructure
Uses aptamer-based detection for fast, low-cost, high-accuracy, high-multiplex diagnostics.
#Diagnostics / Aptamer-based detection
Developing cyclotides to deliver proteins (enzymes, antibodies, growth factors) across the blood–brain barrier.
#Biotechnology / CNS delivery
Portable solar/battery towers for lights, communications, security for construction, first responders, events; no tow-hitch design.
#CleanTech / Portable power
Developing antibodies targeting haptens of inhibited KRAS12C; derived from UCSF labs.
#Biotherapeutics / Antibodies
Develops potent, bitopic-binding small molecule inhibitors of HDAC6 for neurologic and cardiovascular indications.
#Small-molecule therapeutics / Neurology & cardiovascular
Develops cancer vaccines targeting human endogenous retrovirus.
#Immuno-oncology / Cancer vaccines
Has exclusive access in China to BioAtla’s CAB therapeutics to treat cancer.
#Oncology / Biotherapeutics
Uses AI to map the metabolome of the human microbiome (skin and gut) to find immunomodulating agents, starting with eczema then IBD.
#Microbiome / Biotech
FDA-cleared minimally invasive devices that retrieve and aspirate clots in legs (DVT) or lungs (PE).
#MedTech / Vascular devices
Provides tools for landlords to leverage VNEM to add solar to apartments profitably.
#CleanTech / Distributed solar
Revolutionary process to manufacture solar cells without wafers.
#CleanTech / Solar manufacturing
Non-contact overnight monitoring to predict COPD exacerbations and prevent hospitalization.
#Digital health / Remote monitoring
Described as having cell-specific in-vivo gene delivery with no liver sink and no immunogenicity.
#Gene delivery / Biotech
Developing an electronic implantable device to correct atrial fibrillation.
#MedTech / Cardiac devices
Advancing progenitor muscle stem cells to treat muscular dystrophies.
#Cell therapy / Regenerative medicine
Increases solubility of drugs without solvents or stabilizers; applicable for intranasal and inhalable formulations.
#Drug formulation / Delivery
Manufactures DNA plasmids using a proprietary bacterial strain as a drop-in replacement for E. coli.
#Biomanufacturing / Plasmid production
AI system to generate mini-proteins delivering leads with higher affinity faster than typical antibody screening.
#Protein engineering / AI-driven discovery
Develops lipid nanoparticles for oral delivery of mRNA to the intestine.
#Drug delivery / LNPs
Developed a rapid screening system to find protein-specific inhibitors of palmitoylation; first target pan-NRAS-mutant cancers.
#Drug discovery / Screening
Developing the first minimally invasive heart-assist device.
#MedTech / Cardiac assist devices
Improving diagnosis and treatment of prostate cancer.
#MedTech / Oncology diagnostics
Developing a small molecule to reverse the course of multiple sclerosis.
#Small-molecule therapeutics / Neurology
Developing stents for lungs to keep airways open.
#MedTech / Pulmonary devices
Developing personalized, durable cancer vaccines using patient-derived, modified cancer cells.
#Immuno-oncology / Cancer vaccines
AI-based differential diagnosis at point of care using ground-truth sources (e.g., JAMA, BMJ) to support clinicians.
#AI / Clinical decision support
Delivers natural adenosine to regrow cartilage and reverse arthritis.
#Biologics / Regenerative medicine
Novel gene therapy delivery platform using proprietary LNPs to turn fat cells into protein factories; single injection example producing stable GLP1 for 3+ years and adjustable dosing.
#Gene therapy delivery / LNPs
In Phase 3 trials for a drug-device combo delivering chemo via minimally invasive catheter; interim results show doubled PFS and reduced toxicity in locally advanced pancreatic cancer.
#Oncology / Drug-device combination
Converts waste plastic into diesel or naphtha via microwave pyrolysis.
#CleanTech / Waste-to-fuel
Robotics and AI to autonomously prepare, image, and assess tissue during biopsy procedures.
#Robotics / Pathology
Developing a device to process solid tissues into single cells or nuclei for sequencing.
#Genomics / Single-cell processing
Rapidly modifies a patient’s own macrophages to elicit a broad-spectrum immune response to fight cancer locally and vaccinate systemically.
#Cell therapy / Immuno-oncology
Developing novel quadrivalent bi-specifics to fight cancer.
#Biologics / Oncology
Developing multiple novel therapies for vascular disease and heart failure.
#Cardiovascular / Therapeutics
Building a global marketplace for design, optimization, and procurement of onsite energy systems.
#Energy marketplace / CleanTech
Redirecting previously acquired viral immunity to fight cancer; noted in blog for a $125M license deal (see news).
#Immuno-oncology / Therapeutics
Developed an eyedrop (not injection) to treat wet AMD and DME; targets a $15B market.
#Ophthalmology / Therapeutics
Developing a pill to address obesity.
#Pharmaceuticals / Obesity therapeutics
Listed as 'ACQUIRED by Novartis in a $1B deal' for technology enabling delivery of siRNA therapies.
#RNA delivery / Biotech
Listed as 'ACQUIRED. Developed a collaborative online learning platform.'
#EdTech
Listed as 'ACQUIRED. Developed rapid genetic testing of cancer-biopsy samples.'
#Diagnostics / Genetics