Repurposed Therapeutics, Inc.
Defender Pharmaceuticals is a privately held life sciences company based in St. Louis, MO, focused on developing innovative therapies to offer patients a sense of security and strength. The company aims to address challenging and potentially life-threatening conditions through novel science, leveraging the expertise of its team and partnerships with established institutions. Their work includes collaborations with the Department of Defense, NASA, and the Department of Veterans Affairs to improve health outcomes for both civilian and military populations.
Industries
Nr. of Employees
small (1-50)
Repurposed Therapeutics, Inc.
St Louis, Missouri, United States, North America
Products
Investigational intranasal scopolamine gel
An investigational intranasal gel formulation of scopolamine developed to prevent or mitigate motion-induced nausea and vomiting; completed a pivotal Phase III trial with positive efficacy outcomes, submitted for regulatory review via a New Drug Application (NDA), and subsequently received a regulatory Complete Response Letter (CRL) prompting planned regulatory meetings and remediation planning.
Investigational intranasal scopolamine gel
An investigational intranasal gel formulation of scopolamine developed to prevent or mitigate motion-induced nausea and vomiting; completed a pivotal Phase III trial with positive efficacy outcomes, submitted for regulatory review via a New Drug Application (NDA), and subsequently received a regulatory Complete Response Letter (CRL) prompting planned regulatory meetings and remediation planning.
Services
Collaborative government R&D partnerships
Co-development of clinical programs and operational evaluations with government agencies to test intranasal formulations and other investigational products in specialized populations.
Licensing and IND transfer development services
Acquisition and development of investigational vaccine and therapeutic programs transferred from government laboratories, including access to INDs, data sets, and biological materials.
Clinical development and trial execution services
End-to-end clinical study conduct including randomized controlled trials, cross-over designs, open-label feasibility studies, data collection and endpoint analysis, with CRO coordination where applicable.
Collaborative government R&D partnerships
Co-development of clinical programs and operational evaluations with government agencies to test intranasal formulations and other investigational products in specialized populations.
Licensing and IND transfer development services
Acquisition and development of investigational vaccine and therapeutic programs transferred from government laboratories, including access to INDs, data sets, and biological materials.
Clinical development and trial execution services
End-to-end clinical study conduct including randomized controlled trials, cross-over designs, open-label feasibility studies, data collection and endpoint analysis, with CRO coordination where applicable.
Expertise Areas
- Intranasal formulation and delivery
- Phase 2–3 clinical trial management
- Regulatory submissions and FDA engagement
- Pharmacokinetics and clinical pharmacology
Key Technologies
- Intranasal gel formulations
- Intranasal delivery vehicles and mucosal absorption
- Pharmacokinetic (PK) profiling
- Randomized double-blind and cross-over clinical trial designs