Reprotox
Developer of in vitro reproductive-toxicology platforms focused on 3D testicular organoid and organotypic culture models across species and developmental stages, combined with automated high-content imaging and machine-learning single-cell analysis to predict male reproductive toxicity and reduce animal use.
Industries
Nr. of Employees
small (1-50)
Reprotox
800 Bradbury Dr. SE, Suite 150, Science & Technology Park, University of New Mexico, Albuquerque, NM 87106
Products
Multi-species 3D testicular organoid models
In vitro organoid models derived from mouse, rat and canine testicular cells representing developmental stages of spermatogenesis for use in toxicity testing and preclinical studies.
High-content analysis assay suite and ML pipeline
Suite of fluorescent-based high-content assays and a machine-learning analysis pipeline for single-cell phenotypic profiling across multiple toxicological endpoints.
Primary Sertoli and testicular cell preparations
Isolation, culture, expansion and supply protocols for primary Sertoli and other testicular cell types intended for assay use.
Multi-species 3D testicular organoid models
In vitro organoid models derived from mouse, rat and canine testicular cells representing developmental stages of spermatogenesis for use in toxicity testing and preclinical studies.
High-content analysis assay suite and ML pipeline
Suite of fluorescent-based high-content assays and a machine-learning analysis pipeline for single-cell phenotypic profiling across multiple toxicological endpoints.
Primary Sertoli and testicular cell preparations
Isolation, culture, expansion and supply protocols for primary Sertoli and other testicular cell types intended for assay use.
Services
Development of 3D testicular organoid cultures representing multiple species and developmental stages for preclinical testing and disease modelling.
Automated high-throughput screening and high-content analysis services using fluorescent microplate assays and multiplexed endpoints for reproductive toxicity evaluation.
Culture service that preserves seminiferous tubule architecture and Sertoli cell polarity for studies of spermatogenesis phases.
Customized assay campaigns using organoid and primary cell models with multiplexed high-content endpoints to evaluate compound safety and mode-of-action.
Development of 3D testicular organoid cultures representing multiple species and developmental stages for preclinical testing and disease modelling.
Automated high-throughput screening and high-content analysis services using fluorescent microplate assays and multiplexed endpoints for reproductive toxicity evaluation.
Culture service that preserves seminiferous tubule architecture and Sertoli cell polarity for studies of spermatogenesis phases.
Customized assay campaigns using organoid and primary cell models with multiplexed high-content endpoints to evaluate compound safety and mode-of-action.
Expertise Areas
- Reproductive toxicology testing
- In vitro organoid and organotypic model development
- High-content image analysis and machine-learning phenotyping
- High-throughput screening (HTS) and assay automation
Key Technologies
- 3D organoid culture
- Organotypic seminiferous tubule culture
- High-content imaging (HCI)
- Machine learning for image analysis
News & Updates
Study using high-content single-cell analysis to profile testicular cell-type-specific toxicity of bisphenol A and analogs.
Protocol and characterization of primary canine Sertoli cell isolation, culture, and application in high-content assays.
Description of a 3D testicular co-culture model and HCA pipeline for predicting testicular toxicity induced by bisphenol compounds.
Awarded NIH SBIR Phase I funding for technology development.
Awarded NIH SBIR Phase II funding to support further development.
Recipient of an NIH prize focused on complementing animal research alternatives.
Study using high-content single-cell analysis to profile testicular cell-type-specific toxicity of bisphenol A and analogs.
Protocol and characterization of primary canine Sertoli cell isolation, culture, and application in high-content assays.
Description of a 3D testicular co-culture model and HCA pipeline for predicting testicular toxicity induced by bisphenol compounds.
Awarded NIH SBIR Phase I funding for technology development.
Awarded NIH SBIR Phase II funding to support further development.
Recipient of an NIH prize focused on complementing animal research alternatives.