Rapid Novor

Epitope mapping for hundreds of antibodies against one antigen using integrated AI.

Epitope mapping for 10 to 50 antibodies against one antigen.

Characterize linear and conformational epitopes for expressed antibody products against target antigens.

Validate the target antigen by identifying the binding epitopes, ensuring specificity and efficacy of the antibody.

Service matching the masses of individual peptides to expected masses calculated from a given sequence to maximize coverage and confidence in sequence confirmation.

Confirm protein sequences and pinpoint the occurrences of any modifications, mispairings, or mutations after protein expression or during cell line development.

Routinely certify immunoreagents by confirming the expected sequence for the highest quality with minimal troubleshooting.

Strengthen patent applications with functional data by characterizing specific binding properties and confirming sequence details.

Locate and quantify close variants of your primary sequence within your sample via our Sequence Variant Analysis LC-MS service.

Service to identify errors in recombinant expression such as single point mutations, amino acid substitutions, or contaminants very early in the process.

Identification and quantification of disulfide bonds by LC-MS, designed for monoclonal antibodies (mAbs) to analyze correct folding conformation and disulfide bond shuffling.

Characterize the glycan profile and pinpoint glycosylation sites that influence antibody functions for specific therapeutic purposes.

Discover the locations and relative quantities of common glycans using liquid chromatography and mass spectrometry.

An antibody discovery service that sequences the population of polyclonal antibodies directly from serum and screens, validates, and analyzes candidate antibodies using kinetic profiling by surface plasmon resonance (SPR).

Obtain amino acid sequences of functional antibodies to facilitate in silico design, rational engineering, humanization, chimerization, affinity maturation, and conjugation design.

An anti-idiotype antibody discovery workflow applying functional enrichment prior to sequencing, enabling precise identification of high-affinity, low-background binders using the REpAb mass spectrometry-based antibody sequencing platform.

Deep expertise working with antibodies, high throughput mass spectrometry and advanced software to provide critical insights into antibody performance.

Mass spectrometry-based epitope mapping service to identify the binding site of an antibody to its corresponding antigen.

Surface Plasmon Resonance (SPR) service to determine on-rate, off-rate, dissociation constant, and antibody affinity for antibody-antigen interactions.

A routine, fast, and easy peptide mapping solution to verify antibodies, reduce risk, and increase reproducibility at every step of workflow development.

Custom analysis of protein complexes, conformation changes, ligands, and other structural questions.

Surface Plasmon Resonance service to determine the on-rate, off-rate, dissociation constant, and affinity for antibody-antigen interactions.

An immune response profiling service to enhance the examination of the humoral immune response in different conditions including immunity cohort studies.

Intact protein analysis service by mass spectrometry for characterizing monoclonal antibodies, providing high-throughput confirmation, glycan analysis, and drug-antibody ratio analysis.

Validate AI-designed antibodies with real-time kinetics, measuring on/off rates and affinities to rank candidates by binding quality.

Sequencing of mAbs, scFvs, and Fabs for the rational design of capsid proteins for improved transduction and immunogenicity.

Convert your polyclonal-based assay to a recombinant form, for increased reproducibility, and avoid costly re-validation.

Discover new antigen binding regions by examining the functional native immune response and sequencing patient antibodies.

Label-free evaluation of antibody-antigen binding through Surface Plasmon Resonance (SPR) to deliver high sensitivity and minimal noise.

Detailed PTM and glycan analysis to assess antibody stability, integrity, and manufacturability.

Species switching and Fc silencing services starting with sequencing what works, followed by engineering, expression, and sequence confirmation.

Our antibody expression service bundles offer protein sequencing plus expression: the fastest and highest-quality protein production of grams to milligrams of recombinant antibodies in either HEK or CHO cells.

Derive custom anti-drug antibody control reagents from circulating pAbs without culling the producer animal for improved ADA assays.

Differential analysis service to evaluate levels of oxidation, deamidation, truncation, and clipping of proteins.

Identify crucial post-translational modifications (PTMs), disulfide bonds, and glycan profiles of biosimilar candidates to facilitate comparative functional evaluations.

Identify sequence variations and demonstrate similarities/differences between the biosimilar and the reference mAb with peptide mapping.

Locate, identify and quantify post-translational modifications. Compare between samples.

Save time troubleshooting cell line stability issues throughout your pipeline, and routinely confirm that the sequences of manufactured immunoreagents match the expected sequences.

Identify the glycan profile and distribution within the host-expression system to facilitate selection and scaling of production.