Pearl Antigenics
Pearl Antigenics is a full-service repository of monoclonal antibodies (MAbs) and recombinant proteins targeting _Trichomonas vaginalis_, the most common non-viral sexually transmitted infection (STI) worldwide. The company focuses on developing rapid, inexpensive point-of-care diagnostics and research reagents for STI prevention and study, especially in resource-poor environments and underdeveloped countries. Their extensive inventory includes monoclonal antibodies recognizing various _T. vaginalis_ proteins, such as RNA-binding proteins, phosphoglucomutase, phosphomannomutase, glyceraldehyde-3-phosphate dehydrogenase, and surface proteins regulated by iron and contact. They also develop recombinant proteins, such as immunogenic metabolic enzyme epitopes and chimeric String-Of-Epitopes (SOE) proteins, which are used for diagnostics, research, and vaccine development. The company is led by Dr. John F. Alderete, a renowned scientist in the field.
Industries
Nr. of Employees
small (1-50)
Pearl Antigenics
Products
Chimeric multi-epitope recombinant antigen (~40 kDa)
Recombinant chimeric antigen composed of concatenated immunogenic epitopes derived from multiple metabolic proteins for serodiagnostic use.
Chimeric multi-epitope recombinant antigen (~49 kDa)
Recombinant chimeric antigen containing repeated and non-unique immunogenic epitopes from multiple metabolic proteins; publications note potential cross-reactivity with human proteins.
α-Actinin antigen (full-length) and associated monoclonal antibodies
Full-length pathogen α-actinin protein provided with multiple monoclonal antibodies for serologic screening and research on host seropositivity.
Adhesin antigens and associated monoclonal antibodies (e.g., ~65 kDa, ~33 kDa)
Adhesin protein reagents and associated monoclonal antibodies used to study host-cell adherence, environmental regulation of expression, and host-protein binding.
Phenotypically variable surface protein reagent (~270 kDa)
High molecular weight surface protein exhibiting phenotypic variation provided with reagents to classify isolate types and study regulation.
Viral capsid protein reagent and detecting monoclonal antibody (~75 kDa)
Capsid protein and monoclonal antibody used to detect double-stranded RNA virus presence in isolates and to assess clonality in localized studies.
Chimeric multi-epitope recombinant antigen (~40 kDa)
Recombinant chimeric antigen composed of concatenated immunogenic epitopes derived from multiple metabolic proteins for serodiagnostic use.
Chimeric multi-epitope recombinant antigen (~49 kDa)
Recombinant chimeric antigen containing repeated and non-unique immunogenic epitopes from multiple metabolic proteins; publications note potential cross-reactivity with human proteins.
α-Actinin antigen (full-length) and associated monoclonal antibodies
Full-length pathogen α-actinin protein provided with multiple monoclonal antibodies for serologic screening and research on host seropositivity.
Adhesin antigens and associated monoclonal antibodies (e.g., ~65 kDa, ~33 kDa)
Adhesin protein reagents and associated monoclonal antibodies used to study host-cell adherence, environmental regulation of expression, and host-protein binding.
Phenotypically variable surface protein reagent (~270 kDa)
High molecular weight surface protein exhibiting phenotypic variation provided with reagents to classify isolate types and study regulation.
Viral capsid protein reagent and detecting monoclonal antibody (~75 kDa)
Capsid protein and monoclonal antibody used to detect double-stranded RNA virus presence in isolates and to assess clonality in localized studies.
Services
Provision and licensing of characterized monoclonal antibodies and recombinant antigens via an online catalog and inquiry-driven ordering process.
Consultative engagement and project-based collaboration for assay development, reagent provision and research studies with external partners.
Provision of availability, custom sourcing and pricing information for specific monoclonal antibodies and recombinant antigens on request.
Provision and licensing of characterized monoclonal antibodies and recombinant antigens via an online catalog and inquiry-driven ordering process.
Consultative engagement and project-based collaboration for assay development, reagent provision and research studies with external partners.
Provision of availability, custom sourcing and pricing information for specific monoclonal antibodies and recombinant antigens on request.
Expertise Areas
- Monoclonal antibody development and repository management
- Recombinant multi-epitope antigen design
- Serologic assay development and point-of-care diagnostics
- Immunoassay (ELISA) implementation and validation
Key Technologies
- Monoclonal antibody reagents
- Recombinant protein expression in heterologous systems (E. coli)
- Multi-epitope (string-of-epitopes) recombinant antigen design
- Epitope mapping