OsteoCure Therapeutics
Duke University spinout developing adenosine-based small-molecule therapeutics and biomaterial delivery systems to restore skeletal health. The organization focuses on reversing bone loss and accelerating bone repair, with preclinical evidence across fracture-healing and impaired-healing models and publications describing biomaterial-assisted local delivery and mechanistic studies of adenosine signaling.
Industries
Nr. of Employees
small (1-50)
OsteoCure Therapeutics
Products
Adenosine-based bone-regeneration therapeutic platform
A platform combining adenosine-modulating small molecules with biomaterial delivery systems to promote bone formation and accelerate repair in preclinical models.
Adenosine-based bone-regeneration therapeutic platform
A platform combining adenosine-modulating small molecules with biomaterial delivery systems to promote bone formation and accelerate repair in preclinical models.
Expertise Areas
- Bone regeneration therapeutics
- Biomaterials for local drug delivery
- Preclinical fracture-healing models
- Mechanistic studies of bone signaling pathways
Key Technologies
- Adenosine-based small-molecule therapeutics
- Microgel-based local delivery
- In situ-curing scaffolds
- Calcium phosphate matrices
News & Updates
Application of in situ-curing scaffolds containing adenosine-loaded microgels improved bone tissue healing in a mouse tibial fracture model.
Biomaterial-assisted sequestration of small molecules to localize pro-regenerative signaling at injury sites and accelerate bone repair.
Describes a dual role for adenosine and its material-assisted local delivery as a therapeutic approach to treat bone trauma and associated pain.
Shows extracellular phosphate uptake supports osteogenic differentiation of human mesenchymal stem cells via adenosine-related pathways.
Demonstrates direct conversion of human pluripotent stem cells into osteoblast-like cells using adenosine, with production of calcified bone matrix.
Application of in situ-curing scaffolds containing adenosine-loaded microgels improved bone tissue healing in a mouse tibial fracture model.
Biomaterial-assisted sequestration of small molecules to localize pro-regenerative signaling at injury sites and accelerate bone repair.
Describes a dual role for adenosine and its material-assisted local delivery as a therapeutic approach to treat bone trauma and associated pain.
Shows extracellular phosphate uptake supports osteogenic differentiation of human mesenchymal stem cells via adenosine-related pathways.
Demonstrates direct conversion of human pluripotent stem cells into osteoblast-like cells using adenosine, with production of calcified bone matrix.