OrthoSera
OrthoSera Medical Zrt. is Hungary's leading serum development company, utilizing blood regenerative potential and serum therapy for disease treatment and regenerative medicine. They have developed three unique technologies for clinical use, focusing on orthopedics, dentistry, and COVID-19 response, with ongoing research and development in tissue and plasma-based therapies.
Industries
Nr. of Employees
small (1-50)
OrthoSera
Krems, Niederosterreich, Austria, Europe
Products
Albumin-impregnated bone allograft (albumin-coated bone graft)
Mineralized human bone allograft impregnated with serum albumin to enhance stem cell adhesion and bone remodelling for orthopedic and dental augmentation.
Hyperacute serum formulation for intra-articular use
Autologous-derived hyperacute serum formulation intended for intra-articular injection to modulate cytokine milieu and improve symptoms in osteoarthritic knees; available in investigational and optimized lyophilized forms.
Antibiotic-coated bone grafts with polymeric sustained-release layers
Human bone allografts coated with antibiotics and biodegradable polymers (alginate or chitosan) to provide short- or long-term local antibiotic release, characterized in vitro for release duration.
Albumin-coated bioactive sutures for cell transplantation
Absorbable sutures coated with albumin (and alternative adhesives) to enable cell attachment, short manufacturing incubation protocols and in vivo cell delivery for soft tissue repair.
Albumin-impregnated bone allograft (albumin-coated bone graft)
Mineralized human bone allograft impregnated with serum albumin to enhance stem cell adhesion and bone remodelling for orthopedic and dental augmentation.
Hyperacute serum formulation for intra-articular use
Autologous-derived hyperacute serum formulation intended for intra-articular injection to modulate cytokine milieu and improve symptoms in osteoarthritic knees; available in investigational and optimized lyophilized forms.
Antibiotic-coated bone grafts with polymeric sustained-release layers
Human bone allografts coated with antibiotics and biodegradable polymers (alginate or chitosan) to provide short- or long-term local antibiotic release, characterized in vitro for release duration.
Albumin-coated bioactive sutures for cell transplantation
Absorbable sutures coated with albumin (and alternative adhesives) to enable cell attachment, short manufacturing incubation protocols and in vivo cell delivery for soft tissue repair.
Services
Preclinical R&D for serum-derived therapeutics and biomaterials
Design and execution of in vitro and in vivo studies for evaluation of serum-based formulations, albumin-coated grafts and cell-delivery constructs.
Clinical study design and execution for regenerative interventions
Clinical trial conduct including pilot studies and randomized controlled trials with synovial fluid profiling and long-term clinical follow-up.
Tissue processing and allograft preparation
Preparation and handling of human bone allografts including impregnation with albumin and lyophilized processing for clinical implantation.
Formulation and stabilization of serum-derived products (lyophilized formats)
Optimization and production-ready formulation development of lyophilized serum derivatives and combination products for regenerative indications.
Analytical and assay services for immunology and drug-release profiling
Implementation of ELISA, neutralization assays, spectrophotometric release testing and multivariate statistical analyses for product characterization.
Bioreactor-based MSC expansion and EV production
Scale-up cell culture using microcarriers and vertical-wheel bioreactors to expand stromal cells and produce extracellular vesicles.
Preclinical R&D for serum-derived therapeutics and biomaterials
Design and execution of in vitro and in vivo studies for evaluation of serum-based formulations, albumin-coated grafts and cell-delivery constructs.
Clinical study design and execution for regenerative interventions
Clinical trial conduct including pilot studies and randomized controlled trials with synovial fluid profiling and long-term clinical follow-up.
Tissue processing and allograft preparation
Preparation and handling of human bone allografts including impregnation with albumin and lyophilized processing for clinical implantation.
Formulation and stabilization of serum-derived products (lyophilized formats)
Optimization and production-ready formulation development of lyophilized serum derivatives and combination products for regenerative indications.
Analytical and assay services for immunology and drug-release profiling
Implementation of ELISA, neutralization assays, spectrophotometric release testing and multivariate statistical analyses for product characterization.
Bioreactor-based MSC expansion and EV production
Scale-up cell culture using microcarriers and vertical-wheel bioreactors to expand stromal cells and produce extracellular vesicles.
Expertise Areas
- Serum-based regenerative therapies
- Biomaterials for bone regeneration
- Bone allograft processing and tissue banking
- Cell therapy delivery (suture-based and scaffold approaches)
Key Technologies
- Albumin impregnation/coating of biomaterials
- Lyophilization / freeze-drying
- Alginate and chitosan polymer coatings for sustained release
- Microcarrier suspension culture in vertical-wheel bioreactors