NOTA Laboratories LLC
NOTA Laboratories is focused on developing innovative nitric oxide (NO) delivery systems and applications to treat and prevent a wide range of life-threatening illnesses and conditions. Their mission is to harness the therapeutic properties of NO as an antimicrobial, antiviral, anti-inflammatory, and anti-thrombotic agent across various medical fields. Founded in 2014, the company has developed proprietary platform technologies, including the NOGEN and LANOR systems, which generate NO on-demand for medical use. They are engaged in multiple applications such as neonatal pulmonary hypertension, open heart surgery, respiratory infections, COPD, and catheter lock solutions, with a focus on safety, efficacy, and cost-effectiveness.
Industries
Nr. of Employees
small (1-50)
NOTA Laboratories LLC
Ann Arbor, Michigan, United States, North America
Products
Electrochemical on-demand NO generation system for hospital use
A cartridge-based electrochemical system that generates regulated high-concentration nitric oxide for extended clinical applications (e.g., extracorporeal sweep gas), controlled via current/voltage and in-line sensing.
Photochemical UV-LED NO generation system for portable/home use
A compact system using UV/LED illumination of a coated film cassette to photochemically release and modulate nitric oxide; design emphasizes low cost, small size, and battery operation for ambulatory and home settings.
NO-releasing catheter lock and disposable infection-control formats
Local NO-releasing formulations and disposable products designed to prevent microbial growth and clotting in catheter lines and to provide single-use infection-control options (examples include topical sprays, mask sachets, and catheter disposables).
Electrochemical on-demand NO generation system for hospital use
A cartridge-based electrochemical system that generates regulated high-concentration nitric oxide for extended clinical applications (e.g., extracorporeal sweep gas), controlled via current/voltage and in-line sensing.
Photochemical UV-LED NO generation system for portable/home use
A compact system using UV/LED illumination of a coated film cassette to photochemically release and modulate nitric oxide; design emphasizes low cost, small size, and battery operation for ambulatory and home settings.
NO-releasing catheter lock and disposable infection-control formats
Local NO-releasing formulations and disposable products designed to prevent microbial growth and clotting in catheter lines and to provide single-use infection-control options (examples include topical sprays, mask sachets, and catheter disposables).
Services
Joint development and manufacturing partnerships
Collaborative product and engineering development agreements with manufacturing partners to scale device production and integrate with existing medical equipment.
Research collaborations and preclinical evaluation
Collaborative preclinical studies using in vitro and in vivo models to assess antimicrobial, antiviral, and respiratory effects of NO-based therapeutics.
Regulatory affairs and clinical development support
Regulatory planning and strategy support drawing on regulatory leadership experience to advance investigational products toward clinical evaluation.
Embedded software and device control development
Development of embedded controllers and sensor-driven dosing systems for regulated therapeutic gas delivery, aligned with medical device software standards.
Joint development and manufacturing partnerships
Collaborative product and engineering development agreements with manufacturing partners to scale device production and integrate with existing medical equipment.
Research collaborations and preclinical evaluation
Collaborative preclinical studies using in vitro and in vivo models to assess antimicrobial, antiviral, and respiratory effects of NO-based therapeutics.
Regulatory affairs and clinical development support
Regulatory planning and strategy support drawing on regulatory leadership experience to advance investigational products toward clinical evaluation.
Embedded software and device control development
Development of embedded controllers and sensor-driven dosing systems for regulated therapeutic gas delivery, aligned with medical device software standards.
Expertise Areas
- Nitric oxide delivery systems development
- Medical device design and engineering
- Preclinical infectious disease and respiratory models
- Respiratory and cardiovascular therapeutic applications
Key Technologies
- Electrochemical nitric oxide generation
- Photochemical UV-LED nitric oxide generation from donor films
- NO‑releasing polymers and chemistries
- Sensor-integrated dosing control systems