Nirmidas Biotech


Developer and supplier of near-infrared (NIR-I and NIR-II/SWIR) imaging systems, plasmonic gold microarray substrates, high-sensitivity multiplexed bioassays, and a portfolio of NIR dyes and nanoparticle probes for research and preclinical applications. The company provides assay development and testing services, manufactures plasmonic-modified slides and gold-coated microplates under an ISO13485 quality system, and has experience with regulatory interactions including FDA Emergency Use Authorization and CE/IVDR registration.

Industries

Biotechnology
Health Care
Health Diagnostics
Manufacturing
Biotechnology Research

Nr. of Employees

small (1-50)

Nirmidas Biotech

Palo Alto, California, United States


Patents

Assays, sensing platforms, and methods for diagnosis of coronavirus infection and re-infection

US-11644465-B2

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Methods and systems for diagnosis and treatment of viral infections

US-11022611-B2

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Products

Plasmonic gold microarray slides (barcoded / nonbarcoded / customizable)

Nanostructured gold-coated microarray slides for fluorescence-enhanced multiplex assays and microarray printing; used in low-volume ELISA-like assay formats.

Gold-coated 96-well microplates and plasmonic-coated microplates

Gold-coated microplates enabling electrical conductivity, surface modification, fluorescence enhancement and surface-enhanced Raman applications; available in multiple well formats.

Dual-channel NIR confocal microarray scanner

Confocal scanner for visible and near-infrared channels (including 700–800 nm) to image tissues, cells and microarrays with high signal-to-background for multiplex assays.

Small-animal NIR-II/SWIR fluorescence imaging systems

Imaging platforms for in vivo small-animal fluorescence and bioluminescence covering visible through SWIR wavelengths (reported up to 1700 nm) with high-frame-rate video and lifetime imaging capability for deep-tissue, high-resolution imaging.

Portfolio of NIR-I / NIR-II dyes and probes (organic dyes, QDs, rare-earth NPs, SWNT, gold clusters)

A set of research-use fluorophores and nanoparticle probes with varied excitation/emission profiles (including NIR-II and NIR-IIb emitters), functional groups for conjugation, and characterized circulation/excretion behavior for in vivo/ex vivo applications.

Research-use serology and antigen/antibody kits

Assay kits and controls for multiplexed antibody (IgG/IgM/IgA) detection and antigen detection in research use formats, including small-volume assays and rapid lateral-flow formats for serology evaluation.

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Services

Design and delivery of customized multiplexed bioassays and testing services using plasmonic-enhanced substrates and compatible imaging/readout systems for research and preclinical applications.

Expertise Areas

  • Near-infrared (NIR-I and NIR-II/SWIR) in vivo imaging
  • Plasmonic-enhanced fluorescence diagnostics
  • Multiplexed serology and protein microarray assays
  • NIR dye and nanoparticle probe design
  • Show More (3)

Key Technologies

  • Near-infrared II (NIR-II/SWIR) fluorescence imaging (1000–1700 nm)
  • Plasmonic gold microarray substrates
  • Dual-channel confocal microarray scanners
  • Quantum dot probes (PbS/CdS core-shell)
  • Show More (6)

News & Updates

Company co-founder interviewed in Nature Photonics to discuss developments in NIR-II bioimaging and clinical potential (April 13, 2023).

Received FDA Emergency Use Authorization for a rapid COVID-19 antibody fingerstick test.

Extended shelf life for specific lots of a COVID-19 antibody combo detection kit to comply with FDA shelf-life testing updates.

Plasmonic microarray slides produced under an ISO 13485 quality system and registered under CE IVDR for device products.

Announcement of a small-animal imaging system capable of NIR-II/SWIR detection and associated NIR-II probes for preclinical research.

Entered a five-year agreement with a CLIA-certified laboratory to develop LDT serology tests using plasmonic microarray platforms.

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