Microsize


Contract development and manufacturing organization (CDMO) focused on cGMP micronization and particle engineering for pharmaceutical APIs and excipients. Operates US-based, FDA-inspected facilities and provides development through commercial scale-up for particle size reduction, classification, analytical characterization, and high-potency containment.

Industries

Medical Device
Pharmaceutical
Pharmaceutical Manufacturing

Nr. of Employees

small (1-50)

Microsize

Quakertown, Pennsylvania, United States


Products

Classification

Vibratory screening service utilizing adjustable concentric weights to direct powder for simultaneous multiple cuts and separation of oversize or fines.

Classification via Air Swept (Turbo) Screening

Air swept screening service providing improved throughput and efficiency for lower bulk density powders using negative draw and pneumatic conveying.

Precision Micronization

First-choice technology and cost-effective solution for enhancing dissolution and bioavailability of drug candidates via particle size reduction.

High Potency Containment Services

HPAPI micronization services utilizing specialized suites and isolators qualified to meet OEB 6 levels (down to 50 ng/m3) for highly sensitizing, potent, and cytotoxic compounds.

Short Term Stability Analysis

Evaluate physical stability of pre- and post-micronized material to assess potential for phase changes.


Services

Contract micronization services using jet and co-jet milling for APIs and excipients at development and commercial scale.

Screening and classification services to control particle fractions and powder flow using multiple classification technologies.

Development and execution of PSD methods, laser diffraction, and morphology analysis for process monitoring and product release.

Containment solutions (hard-wall and single-use) and procedures for handling highly potent compounds and controlled substances under cGMP.

End-to-end development and scale-up of micronization processes under cGMP from early development to commercial production.

Expertise Areas

  • Micronization and jet milling
  • Particle engineering for solubility and bioavailability
  • Particle characterization and PSD method development
  • Containment for high-potency APIs
  • Show More (4)

Key Technologies

  • Jet milling
  • Co-jet milling
  • Laser diffraction
  • Particle size distribution (PSD) analysis
  • Show More (4)

News & Updates

Attending and hosting meetings at multiple industry conferences in 2025 (BIO, ChemOutsourcing, CPhI, AIChE, and local events).

White paper discussing the interplay of salt formation and particle size reduction to maximize bioavailability of poorly soluble APIs.

Discussion of feeder technology options to minimize material loss and ensure precise feed rates for limited-quantity development work.

Examination of co-jet milling benefits compared to traditional jet milling for blending, powder flow, and uniform particle size reduction.

Guidance on developing robust PSD methods using laser diffraction for monitoring micronization processes and release testing.

Operates US-based facilities totaling over 100,000 square feet and three facilities noted on public pages.

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