Matinicus Pharma
Developer of a modified hemoglobin-based injectable oxygen carrier and a modular manufacturing platform for purified hemoglobin products. Focus areas include extraction and chemical stabilization of bovine-derived hemoglobin, large-scale purification and scale-up, preclinical evaluation in trauma/ischemia and organ perfusion, and regulatory pathways for veterinary and human use.
Industries
Nr. of Employees
small (1-50)
Matinicus Pharma
Malvern, Pennsylvania, United States
Products
Modified hemoglobin injectable oxygen carrier (m-HPAOC)
An injectable, chemically stabilized and polymerized hemoglobin solution derived from bovine blood designed to deliver dissolved oxygen to tissues and organs; formulated for room-temperature stability and universal compatibility with all blood types.
Oxy-Rx™
Bovine Haemoglobin supplied as an intravenous infusion or added to perfusion fluids to deliver significant therapeutic levels of oxygen to support ischaemic organs following stroke, MI, trauma, acute resuscitation, and solid organ transplantation.
Oxy-Rx
Medical device for organ preservation indicated for the prolonged preservation of organs for transplant during transport or storage and extracorporeal circulation.
Oxyglobin Solution
Oxyglobin Solution hemoglobin glutamer – 200 (bovine) is a hemoglobin-based oxygen carrying fluid indicated for the treatment of anemia in dogs by increasing systemic oxygen content and improving clinical signs associated with anemia.
HBOC-201
A modified hemoglobin oxygen carrier (m-HPAOC) designed to provide oxygenation for injured areas, prevent peripheral tissue injury during mechanical ventilation, and provide adequate organ perfusion during transportation.
Modified hemoglobin injectable oxygen carrier (m-HPAOC)
An injectable, chemically stabilized and polymerized hemoglobin solution derived from bovine blood designed to deliver dissolved oxygen to tissues and organs; formulated for room-temperature stability and universal compatibility with all blood types.
Oxy-Rx™
Bovine Haemoglobin supplied as an intravenous infusion or added to perfusion fluids to deliver significant therapeutic levels of oxygen to support ischaemic organs following stroke, MI, trauma, acute resuscitation, and solid organ transplantation.
Oxy-Rx
Medical device for organ preservation indicated for the prolonged preservation of organs for transplant during transport or storage and extracorporeal circulation.
Oxyglobin Solution
Oxyglobin Solution hemoglobin glutamer – 200 (bovine) is a hemoglobin-based oxygen carrying fluid indicated for the treatment of anemia in dogs by increasing systemic oxygen content and improving clinical signs associated with anemia.
HBOC-201
A modified hemoglobin oxygen carrier (m-HPAOC) designed to provide oxygenation for injured areas, prevent peripheral tissue injury during mechanical ventilation, and provide adequate organ perfusion during transportation.
Services
Licensing of modular manufacturing designs and provision of a documented digital operational package to support equivalent biological product manufacture across sites.
Licensing of modular manufacturing designs and provision of a documented digital operational package to support equivalent biological product manufacture across sites.
Expertise Areas
- Hemoglobin-based oxygen therapeutics
- Organ preservation and ex-vivo perfusion
- Preclinical models for trauma and ischemia
- Biologics purification and scale-up
Key Technologies
- High-performance liquid chromatography (HPLC) for purification
- Membrane filtration methods for large-scale purification
- Gel permeation chromatography for molecular-weight profiling
- Chemical crosslinking/polymerization of proteins
News & Updates
PDF compilation of publications related to hemoglobin-based oxygen carriers and preclinical/clinical studies provided on the site.
Bovine hemoglobin products previously approved for veterinary indications and used in approximately 300,000 treatment episodes across multiple species; veterinary approval initially obtained in 1998.
PDF compilation of publications related to hemoglobin-based oxygen carriers and preclinical/clinical studies provided on the site.
Bovine hemoglobin products previously approved for veterinary indications and used in approximately 300,000 treatment episodes across multiple species; veterinary approval initially obtained in 1998.