Linnaeus Bioscience
Linnaeus Bioscience Inc. is dedicated to accelerating drug discovery, especially in the fight against antibiotic resistant bacteria. Founded in 2012, it develops innovative technologies such as bacterial cytological profiling supported by AI to discover and characterize new antibacterial molecules. The company collaborates with various partners to develop solutions for antimicrobial research and development.
Industries
Linnaeus Bioscience
Products
Image-based bacterial cytological profiling platform
A microscopy-based phenotypic profiling platform that generates quantitative cytological readouts to determine antimicrobial MOA, support hit triage, and provide SAR insights.
AI-driven mycobacterial cytological profiling platform
A mycobacteria-optimized cytological profiling platform integrated with AI to classify MOA for Mycobacterium species and compare novel compounds to a mycobacterial phenotype database.
Fungal cytological profiling platform
Adaptation of phenotypic cytological profiling methods to fungal pathogens to determine antifungal MOA and support early-stage antifungal discovery.
Image-based bacterial cytological profiling platform
A microscopy-based phenotypic profiling platform that generates quantitative cytological readouts to determine antimicrobial MOA, support hit triage, and provide SAR insights.
AI-driven mycobacterial cytological profiling platform
A mycobacteria-optimized cytological profiling platform integrated with AI to classify MOA for Mycobacterium species and compare novel compounds to a mycobacterial phenotype database.
Fungal cytological profiling platform
Adaptation of phenotypic cytological profiling methods to fungal pathogens to determine antifungal MOA and support early-stage antifungal discovery.
Services
Bacterial cytological profiling service
Image-based phenotypic profiling to determine antimicrobial mechanism of action, bin screening hits by MOA, generate SAR data, and monitor target engagement during lead optimization.
Mycobacterial cytological profiling (AI-driven) service
Specialized profiling and AI classification for mycobacterial species to determine MOA, compare phenotypes to a mycobacterial phenotype library, and support tuberculosis drug discovery projects.
MIC testing (broth microdilution, CLSI-compliant)
Minimum inhibitory concentration assays using broth microdilution following CLSI guidelines across bacterial and fungal pathogens with customization of growth media and sample types.
Antimicrobial assays (time-kill, synergy, biofilm, ATP)
A suite of antimicrobial assays including time-kill kinetics, checkerboard synergy testing, cellular ATP bioenergetic assays, and biofilm eradication testing to characterize compound activity.
Fungal cytological profiling and antifungal assays
Image-based cytological profiling and antifungal assay development for fungal pathogens to characterize MOA and support lead selection.
Bacteriophage assays and phage characterization
Potency and susceptibility testing, high-throughput phage–bacteria assays, time-to-lysis kinetics, phage MOA studies, receptor identification, resistance frequency assessment, and phage–antibiotic synergy testing.
Bacterial cytological profiling service
Image-based phenotypic profiling to determine antimicrobial mechanism of action, bin screening hits by MOA, generate SAR data, and monitor target engagement during lead optimization.
Mycobacterial cytological profiling (AI-driven) service
Specialized profiling and AI classification for mycobacterial species to determine MOA, compare phenotypes to a mycobacterial phenotype library, and support tuberculosis drug discovery projects.
MIC testing (broth microdilution, CLSI-compliant)
Minimum inhibitory concentration assays using broth microdilution following CLSI guidelines across bacterial and fungal pathogens with customization of growth media and sample types.
Antimicrobial assays (time-kill, synergy, biofilm, ATP)
A suite of antimicrobial assays including time-kill kinetics, checkerboard synergy testing, cellular ATP bioenergetic assays, and biofilm eradication testing to characterize compound activity.
Fungal cytological profiling and antifungal assays
Image-based cytological profiling and antifungal assay development for fungal pathogens to characterize MOA and support lead selection.
Bacteriophage assays and phage characterization
Potency and susceptibility testing, high-throughput phage–bacteria assays, time-to-lysis kinetics, phage MOA studies, receptor identification, resistance frequency assessment, and phage–antibiotic synergy testing.
Expertise Areas
- Mechanism-of-action determination
- Image-based phenotypic profiling
- Antimicrobial assay development
- High-throughput screening and hit triage
Key Technologies
- Fluorescence microscopy
- Quantitative live-cell imaging
- High-content, image-based phenotypic profiling
- Deep learning / computer vision for image analysis