LifeSensors
LifeSensors Inc. is a biotech company dedicated to advancing research and drug discovery in the fields of ubiquitin proteasome system, PROTACs, molecular glues, and neurodegeneration diagnostics. They collaborate with pharma and biotech partners, providing innovative tools, assays, products, and services to facilitate understanding and targeting of the ubiquitin system for therapeutic development.
Industries
Nr. of Employees
small (1-50)
Products
Bead‑immobilized tandem ubiquitin‑binding affinity matrices (pan- and linkage‑selective)
Bead-immobilized tandem ubiquitin-binding reagents for enrichment and pulldown of polyubiquitinated proteins, available in pan-selective and linkage‑selective formats and in agarose and magnetic bead presentations.
Internally‑quenched di‑ubiquitin FRET substrates
Linkage-defined di‑ubiquitin substrates configured as internally-quenched FRET pairs to report isopeptidase (DUB) cleavage by fluorescence increase; panels available for multiple linkages to support specificity and kinetic studies.
High-throughput plate-based assay kits (colorimetric and chemiluminescent)
Plate kits and consumables configured for high‑throughput evaluation of ubiquitination and degradation activity, available in colorimetric and chemiluminescent readouts and compatible with HTS workflows.
SUMO‑family expression kits and vectors
Kits containing SUMO plasmids, proteases, control proteins and detection reagents to support expression and purification workflows optimized for difficult-to-express proteins across common host systems.
Antibodies for ubiquitin- and SUMO-pathway proteins
Antibodies for detection of SUMO tags, deSUMOylases, deubiquitinases and other ubiquitin-pathway proteins to support expression checks, protease cleavage validation and immunodetection workflows.
Bead‑immobilized tandem ubiquitin‑binding affinity matrices (pan- and linkage‑selective)
Bead-immobilized tandem ubiquitin-binding reagents for enrichment and pulldown of polyubiquitinated proteins, available in pan-selective and linkage‑selective formats and in agarose and magnetic bead presentations.
Internally‑quenched di‑ubiquitin FRET substrates
Linkage-defined di‑ubiquitin substrates configured as internally-quenched FRET pairs to report isopeptidase (DUB) cleavage by fluorescence increase; panels available for multiple linkages to support specificity and kinetic studies.
High-throughput plate-based assay kits (colorimetric and chemiluminescent)
Plate kits and consumables configured for high‑throughput evaluation of ubiquitination and degradation activity, available in colorimetric and chemiluminescent readouts and compatible with HTS workflows.
SUMO‑family expression kits and vectors
Kits containing SUMO plasmids, proteases, control proteins and detection reagents to support expression and purification workflows optimized for difficult-to-express proteins across common host systems.
Antibodies for ubiquitin- and SUMO-pathway proteins
Antibodies for detection of SUMO tags, deSUMOylases, deubiquitinases and other ubiquitin-pathway proteins to support expression checks, protease cleavage validation and immunodetection workflows.
Services
Assay development for targeted protein degradation
Contract assay development and execution to measure ubiquitination, ternary complex formation and target degradation for PROTAC and molecular-glue programs, using in vitro and cell-based formats and enabling target validation.
E3 ligase profiling and screening services
Biochemical and cell-based screening services for E3 ligase activity and ligase-centric ligand discovery, combining gel-based assays, thermal shift, SPR and substrate ubiquitination assays.
Deubiquitinase screening and profiling
Enzymatic assay development and high-throughput screening for deubiquitinases using fluorogenic substrates and internally-quenched di‑ubiquitin panels to determine linkage specificity and kinetics.
Affinity-enrichment proteomics service (ubiquitin-focused)
End-to-end proteomics service combining ubiquitin-affinity pulldown with LC‑MS/MS and bioinformatic analysis to identify and quantify ubiquitinated proteins and modification sites.
SUMO-fusion expression and purification services
Expression system development and protein production using SUMO-family fusion tags across bacterial, yeast, insect and mammalian hosts, with supporting reagents and cleavage proteases.
Translational biomarker and diagnostic assay development (neurodegeneration)
Custom development of biomarker and diagnostic assays focused on neurodegenerative disease applications, translating biochemical activity to cellular and animal models to support diagnostic strategy development.
Assay development for targeted protein degradation
Contract assay development and execution to measure ubiquitination, ternary complex formation and target degradation for PROTAC and molecular-glue programs, using in vitro and cell-based formats and enabling target validation.
E3 ligase profiling and screening services
Biochemical and cell-based screening services for E3 ligase activity and ligase-centric ligand discovery, combining gel-based assays, thermal shift, SPR and substrate ubiquitination assays.
Deubiquitinase screening and profiling
Enzymatic assay development and high-throughput screening for deubiquitinases using fluorogenic substrates and internally-quenched di‑ubiquitin panels to determine linkage specificity and kinetics.
Affinity-enrichment proteomics service (ubiquitin-focused)
End-to-end proteomics service combining ubiquitin-affinity pulldown with LC‑MS/MS and bioinformatic analysis to identify and quantify ubiquitinated proteins and modification sites.
SUMO-fusion expression and purification services
Expression system development and protein production using SUMO-family fusion tags across bacterial, yeast, insect and mammalian hosts, with supporting reagents and cleavage proteases.
Translational biomarker and diagnostic assay development (neurodegeneration)
Custom development of biomarker and diagnostic assays focused on neurodegenerative disease applications, translating biochemical activity to cellular and animal models to support diagnostic strategy development.
Expertise Areas
- Targeted protein degradation (PROTAC and molecular-glue discovery)
- Ubiquitin–proteasome system biology
- E3 ligase profiling and ligand discovery
- Deubiquitinase assay development and screening
Key Technologies
- Affinity enrichment with tandem ubiquitin-binding domains
- Quantitative LC‑MS/MS proteomics
- Internally-quenched di‑ubiquitin FRET substrates
- Fluorogenic ubiquitin-based enzymatic assays