Lankenau Institute for Medical Research
Lankenau Institute for Medical Research (LIMR) is a leading research institute dedicated to studying and developing remedies for cancer, cardiovascular, autoimmune, gastrointestinal, and other diseases. LIMR is at the forefront of the immunotherapy revolution in healthcare, driven by the principle that hope in medicine springs from research. The institute combines a unique mix of academic culture and entrepreneurial spirit, known as the ACAPRENEURIAL™ strategy, to integrate non-profit research with for-profit biotechnology initiatives, fostering a collaborative environment for translating preclinical discoveries into clinical applications.
Industries
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Products
Synovial fluid lateral-flow diagnostic for periprosthetic joint infection
A point-of-care lateral-flow test that detects neutrophil-released peptides in synovial fluid to aid diagnosis of periprosthetic joint infection.
Blood-based predictive assay for chemotherapy-induced delayed nausea
A blood assay intended to predict which patients are at higher risk for delayed-onset nausea from chemotherapy to support pre-treatment risk stratification.
TIMP-4 biomarker assay for prognosis in small triple-negative breast cancers
A laboratory test providing prognostic information to inform aggressiveness assessment and adjuvant chemotherapy decisions for small triple-negative breast cancers.
Human monoclonal antibody recognizing a universal amyloid structural epitope (preclinical)
A patient-derived human monoclonal IgG that binds a conserved structural fold present in diverse amyloid proteins, exhibits amyloid-disaggregating activity in vitro and in vivo, with cloned sequences and hybridomas available for expression and further development.
CellCountEZ rapid cell growth and viability assay
A rapid assay for accurate relative cell counting in tissue culture, linear across a wide dynamic range and suitable for longitudinal monitoring without compromising cell viability.
ThiOx rapid thiol antioxidant capacity assay
A rapid laboratory test to monitor thiol oxidative stress in live cells and tissues.
Synovial fluid lateral-flow diagnostic for periprosthetic joint infection
A point-of-care lateral-flow test that detects neutrophil-released peptides in synovial fluid to aid diagnosis of periprosthetic joint infection.
Blood-based predictive assay for chemotherapy-induced delayed nausea
A blood assay intended to predict which patients are at higher risk for delayed-onset nausea from chemotherapy to support pre-treatment risk stratification.
TIMP-4 biomarker assay for prognosis in small triple-negative breast cancers
A laboratory test providing prognostic information to inform aggressiveness assessment and adjuvant chemotherapy decisions for small triple-negative breast cancers.
Human monoclonal antibody recognizing a universal amyloid structural epitope (preclinical)
A patient-derived human monoclonal IgG that binds a conserved structural fold present in diverse amyloid proteins, exhibits amyloid-disaggregating activity in vitro and in vivo, with cloned sequences and hybridomas available for expression and further development.
CellCountEZ rapid cell growth and viability assay
A rapid assay for accurate relative cell counting in tissue culture, linear across a wide dynamic range and suitable for longitudinal monitoring without compromising cell viability.
ThiOx rapid thiol antioxidant capacity assay
A rapid laboratory test to monitor thiol oxidative stress in live cells and tissues.
Services
Biotech incubator and tenant laboratory services
Leasing of lab and office space, access to shared core facilities and commercialization support for early-stage biotech tenants with flexible cost arrangements.
Chemical genomics and high-throughput screening services
Turnkey HTS services including pooled and combinatorial screening for synergy discovery, access to diverse assay-ready compound libraries and automated compound management.
Cardiac safety assessment services
Integrated cardiac safety testing from ion-channel assays and cardiomyocyte-based assays to ex vivo whole-organ preparations for proarrhythmic risk assessment and regulatory safety support.
Preclinical in vivo studies and vivarium services
Access to an on-site vivarium and support for animal model studies, including housing, husbandry and study coordination for external and internal investigators.
Clinical research center operational support
Centralized infrastructure and administrative support for clinical studies across a health system, facilitating investigator collaborations and supporting specialty research operations.
Antibody discovery and translational development core services
Core facility services for human monoclonal antibody cloning, high-throughput antibody screening including on-cell methods, support for antibody humanization and access to cloned antibody sequences and stored hybridomas for expression and downstream development.
Biotech incubator and tenant laboratory services
Leasing of lab and office space, access to shared core facilities and commercialization support for early-stage biotech tenants with flexible cost arrangements.
Chemical genomics and high-throughput screening services
Turnkey HTS services including pooled and combinatorial screening for synergy discovery, access to diverse assay-ready compound libraries and automated compound management.
Cardiac safety assessment services
Integrated cardiac safety testing from ion-channel assays and cardiomyocyte-based assays to ex vivo whole-organ preparations for proarrhythmic risk assessment and regulatory safety support.
Preclinical in vivo studies and vivarium services
Access to an on-site vivarium and support for animal model studies, including housing, husbandry and study coordination for external and internal investigators.
Clinical research center operational support
Centralized infrastructure and administrative support for clinical studies across a health system, facilitating investigator collaborations and supporting specialty research operations.
Antibody discovery and translational development core services
Core facility services for human monoclonal antibody cloning, high-throughput antibody screening including on-cell methods, support for antibody humanization and access to cloned antibody sequences and stored hybridomas for expression and downstream development.
Expertise Areas
- Clinical trial management and site operations
- Device and interventional clinical study design and early feasibility trials
- Translational research and technology commercialization
- Monoclonal antibody discovery and on-cell hybridoma platforms
Key Technologies
- High-throughput screening (HTS) and pooled/orthogonal screening
- Automated compound management and robotic retrieval
- Patch-clamp and ion-channel electrophysiology (hERG, INa, ICa)
- Action potential recordings and ventricular wedge preparation assays