Evoworks Bio
Developer of an elastically scalable cell-culture platform for protein expression that enables scale-up from small-volume process development to larger batch volumes without equipment changeover. Targets diagnostic antibody developers, CDMOs, and CROs with a single-use vessel and configurable hardware designed to run inside existing incubators. Founded 2023 and based in Cambridge, MA.
Industries
Nr. of Employees
small (1-50)
Products
Single-use culture vessel (EvoNode)
A single-use culture vessel sized for 250–550 mL working volume with sample/feed tubing, semi-permeable membrane for gas exchange, and optional sensor ports for pH, DO, and DCO2.
Mono configuration (parallel development)
Configuration for running up to 12 independent single-use vessels in parallel for screening, condition testing, and early-stage optimization, with optional per-vessel sensing.
Array configuration (elastic scale-up)
Integrated array that connects multiple vessels (up to 18 indicated elsewhere) into a single system with automated single-line fill/drain, replicated conditions across nodes, and scale-up to multi‑liter batches.
LabRack (preclinical scale option)
Higher-capacity system option described as supporting up to ~100 L for preclinical production without equipment re-optimization (referenced as an upgrade path).
EvoNode Array
An integrated array system that connects up to 18 EvoNodes together, replicating ideal conditions across all vessels to achieve on-demand scale-up.
EvoNode Mono
A sophisticated single-use cell culture vessel designed to replace shake flasks, featuring sample and feed tubes, a semi-permeable membrane, and optional sensor ports.
Single-use culture vessel (EvoNode)
A single-use culture vessel sized for 250–550 mL working volume with sample/feed tubing, semi-permeable membrane for gas exchange, and optional sensor ports for pH, DO, and DCO2.
Mono configuration (parallel development)
Configuration for running up to 12 independent single-use vessels in parallel for screening, condition testing, and early-stage optimization, with optional per-vessel sensing.
Array configuration (elastic scale-up)
Integrated array that connects multiple vessels (up to 18 indicated elsewhere) into a single system with automated single-line fill/drain, replicated conditions across nodes, and scale-up to multi‑liter batches.
LabRack (preclinical scale option)
Higher-capacity system option described as supporting up to ~100 L for preclinical production without equipment re-optimization (referenced as an upgrade path).
EvoNode Array
An integrated array system that connects up to 18 EvoNodes together, replicating ideal conditions across all vessels to achieve on-demand scale-up.
EvoNode Mono
A sophisticated single-use cell culture vessel designed to replace shake flasks, featuring sample and feed tubes, a semi-permeable membrane, and optional sensor ports.
Services
Production or pilot execution of client constructs on the provider's platform with delivery of material and run data; options to run in provider facility or ship equipment for in‑lab pilots.
Partnerships and process support for rapid toxicology timelines and production of shear- or oxygen-sensitive biologics using high-oxygen, low-shear architecture.
Platform configurations and application support to scale transient CHO workflows with economics suited to CRO unit costing.
Scientific support covering bispecific production, Rapid Tox timelines, and transient expression workflows; assistance continues after equipment delivery.
Production or pilot execution of client constructs on the provider's platform with delivery of material and run data; options to run in provider facility or ship equipment for in‑lab pilots.
Partnerships and process support for rapid toxicology timelines and production of shear- or oxygen-sensitive biologics using high-oxygen, low-shear architecture.
Platform configurations and application support to scale transient CHO workflows with economics suited to CRO unit costing.
Scientific support covering bispecific production, Rapid Tox timelines, and transient expression workflows; assistance continues after equipment delivery.
Expertise Areas
- Biologics scale-up and process transfer elimination
- Transient CHO expression scaling
- High-throughput cell culture automation
- Bioprocess monitoring and data capture
Key Technologies
- Single-use culture vessels with semi-permeable gas exchange
- Array-based modular bioreactor systems
- Optical sensors for pH, dissolved oxygen, dissolved CO2
- Automated pump systems for fill/drain and feed delivery
News & Updates
Selected as one of five VANGUARD awardees to receive up to $200,000 in non-dilutive funding to advance development of the EvoNode platform; program includes mentorship and engagement with BARDA experts.
Exhibited the platform at a conference focused on rare disease drug development and engaged with rare disease program stakeholders on production challenges.
Company CEO won the Pitch Lift show winner award and advanced to the finals of the Pitch Lift competition.
Selected for the 2025 BioTools Innovator cohort within the BARDA Vanguard specialty track.
Selected as a finalist in the MIT Sloane Healthcare Innovation Prize finals presenting the platform and strategy for bioprocess development.
Accepted into The Engine’s Blueprint program for Tough Tech founders and teams.
Selected as one of five VANGUARD awardees to receive up to $200,000 in non-dilutive funding to advance development of the EvoNode platform; program includes mentorship and engagement with BARDA experts.
Exhibited the platform at a conference focused on rare disease drug development and engaged with rare disease program stakeholders on production challenges.
Company CEO won the Pitch Lift show winner award and advanced to the finals of the Pitch Lift competition.
Selected for the 2025 BioTools Innovator cohort within the BARDA Vanguard specialty track.
Selected as a finalist in the MIT Sloane Healthcare Innovation Prize finals presenting the platform and strategy for bioprocess development.
Accepted into The Engine’s Blueprint program for Tough Tech founders and teams.