Enquyst Technologies


Enquyst Technologies is an innovative bioprocess and analytical technology company founded in 2017, dedicated to developing disruptive equipment and processes to improve biotherapeutic manufacturing. Their mission is to create high-quality, cost-effective biological therapies accessible worldwide by leveraging patented IPP technology that enables continuous manufacturing and ultra-high purity bioproducts.

Industries

biotechnology
manufacturing

Nr. of Employees

small (1-50)

Enquyst Technologies

Lowell, Massachusetts, United States, North America


Products

Isoelectric point-based flow-through purification system (resin-free downstream purification platform)

A modular flow-through purification system that isolates and polishes target biomolecules by leveraging isoelectric point, charge heterogeneity and size; designed for continuous operation, small footprint, closed sterile fluid paths and integrated in-line monitoring.


Services

Downstream process development and optimization

Process development for purification and polishing of biologics across modalities, including experimental design, DoE, and scale-up feedback for equipment design.

Analytical method development, qualification and validation

Development, qualification and validation of bioanalytical and physicochemical assays for biomolecule characterization and in-process testing, including GLP-compliant documentation and SOP authoring.

Bioprocess equipment design and prototyping

Mechanical and electrical engineering services for design, prototyping, testing and iteration of bioprocess equipment, including fluidics, liquid handling and automated control integration.

Pilot implementation of continuous, chromatography-free purification

Pilot-scale deployment and testing of continuous, resin-free purification workflows intended to replace multiple chromatography unit operations and reduce consumables and footprint.

Expertise Areas

  • Downstream process development
  • Continuous biomanufacturing
  • Process intensification for therapeutic proteins
  • Analytical method development and validation
  • Show More (6)

Key Technologies

  • Isoelectric point-based flow-through purification
  • Continuous downstream manufacturing platforms
  • Process Analytical Technology (in-line monitoring)
  • Tangential flow filtration (TFF) / UF-DF
  • Show More (7)

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