Cytognomix
Cytognomix is a London, Ontario biotechnology company that develops software and reagent solutions for clinical genomics, cytogenetics, and radiation biodosimetry. Key activities include genome-scale variant interpretation and splicing analysis, design and production of single-copy genomic probes for FISH and sequence enrichment, automated image-processing software for cytogenetic dose estimation, and associated cloud/HPC deployments. The company maintains an extensive patent portfolio and offers subscription and licensing access to software and probe catalogs.
Industries
Nr. of Employees
small (1-50)
Cytognomix
60 North Centre Rd., Box 27052, London, Ontario N5X 3X5, Canada
Products
Genome-scale mutation interpretation platform (subscription)
A suite of tools for splicing mutation analysis, transcription factor binding site analysis, variant effect prediction, and a user variation database delivered via subscription.
Automated dicentric chromosome identification and dose estimator software
Software that automates detection of dicentric chromosomes and dose estimation from metaphase images, available for workstation, HPC, and secure cloud deployments.
Single-copy FISH probe catalog and custom probe services
Predesigned and custom single-copy FISH probes for high-resolution cytogenetics and diagnostic assays, including subtelomeric and disease-specific probe sets.
Targeted capture reagent panels for NGS
Oligonucleotide capture arrays and pools for targeted deep sequencing of complete gene loci and flanking regions to improve discovery of coding and non-coding variants.
Genomic microarray designs for aCGH
Array comparative genomic hybridization designs using single-copy probe repertoires intended to improve reproducibility and reduce hybridization artifacts.
Genome-scale mutation interpretation platform (subscription)
A suite of tools for splicing mutation analysis, transcription factor binding site analysis, variant effect prediction, and a user variation database delivered via subscription.
Automated dicentric chromosome identification and dose estimator software
Software that automates detection of dicentric chromosomes and dose estimation from metaphase images, available for workstation, HPC, and secure cloud deployments.
Single-copy FISH probe catalog and custom probe services
Predesigned and custom single-copy FISH probes for high-resolution cytogenetics and diagnostic assays, including subtelomeric and disease-specific probe sets.
Targeted capture reagent panels for NGS
Oligonucleotide capture arrays and pools for targeted deep sequencing of complete gene loci and flanking regions to improve discovery of coding and non-coding variants.
Genomic microarray designs for aCGH
Array comparative genomic hybridization designs using single-copy probe repertoires intended to improve reproducibility and reduce hybridization artifacts.
Services
Web-based subscription providing access to genome-scale splicing and variant interpretation pipelines, validation tools, genome browser tracks for probe designs, and a user variation database.
Software and subscription services for automated dicentric chromosome detection and radiation dose estimation, available as workstation, HPC, or cloud deployments; optional consultation for dosimetry.
Manufacture and supply of predesigned and custom single-copy FISH probes (labeled or unlabeled) and subtelomeric probe panels; bulk orders supported; probes validated by hybridization.
Design and provision of oligonucleotide capture pools for targeted sequence enrichment, including complete-gene panels for hereditary cancer and chemotherapy-response targets.
Validation services for probe hybridization, microarray performance, splicing-prediction corroboration with RNA-Seq, and deployment/consulting for biodosimetry at scale.
Web-based subscription providing access to genome-scale splicing and variant interpretation pipelines, validation tools, genome browser tracks for probe designs, and a user variation database.
Software and subscription services for automated dicentric chromosome detection and radiation dose estimation, available as workstation, HPC, or cloud deployments; optional consultation for dosimetry.
Manufacture and supply of predesigned and custom single-copy FISH probes (labeled or unlabeled) and subtelomeric probe panels; bulk orders supported; probes validated by hybridization.
Design and provision of oligonucleotide capture pools for targeted sequence enrichment, including complete-gene panels for hereditary cancer and chemotherapy-response targets.
Validation services for probe hybridization, microarray performance, splicing-prediction corroboration with RNA-Seq, and deployment/consulting for biodosimetry at scale.
Expertise Areas
- Genome-scale mutation interpretation and splicing analysis
- Cytogenetics and high-resolution FISH probe design
- Radiation biodosimetry and dose estimation
- Targeted NGS enrichment and capture reagent design
Key Technologies
- Information theory–based binding-site analysis
- Next-generation sequencing targeted capture arrays
- Single-copy probe (ab initio) design
- Single-copy FISH (scFISH)
News & Updates
Contribution to an open-access Radiobiology textbook (2023) and release of a linked set of 12 video presentations with DOIs deposited on Zenodo and Internet Archive.
Recognition for geostatistical epidemiology analyses of COVID-19 hotspots that informed provincial pandemic response and decision-making.
Presentation on population-scale biodosimetry and related methods at the International Symposium on the System of Radiological Protection (Nov 2022).
Peer-reviewed article describing a secure, cloud-based deployment of automated dicentric chromosome identification and dose estimation software.
US patent issued covering a smart microscope system and data-driven approaches for estimating absorbed radiation dose from microscope-generated data.
Peer-reviewed article describing geostatistical analyses of COVID-19 community transmission and hotspot persistence in Ontario.
Contribution to an open-access Radiobiology textbook (2023) and release of a linked set of 12 video presentations with DOIs deposited on Zenodo and Internet Archive.
Recognition for geostatistical epidemiology analyses of COVID-19 hotspots that informed provincial pandemic response and decision-making.
Presentation on population-scale biodosimetry and related methods at the International Symposium on the System of Radiological Protection (Nov 2022).
Peer-reviewed article describing a secure, cloud-based deployment of automated dicentric chromosome identification and dose estimation software.
US patent issued covering a smart microscope system and data-driven approaches for estimating absorbed radiation dose from microscope-generated data.
Peer-reviewed article describing geostatistical analyses of COVID-19 community transmission and hotspot persistence in Ontario.