Cyrus Biotechnology
Cyrus Bio is an AI-driven discovery company focused on naturally existing proteins that show the potential to be turned into superior therapeutics using AI and deep mutagenesis. The company develops innovative protein design and engineering solutions, with lead programs in severe autoimmune diseases and therapeutic immuno cytokines. They utilize a proven platform with over 30 discovery programs, employing advanced algorithms, laboratory methods, and a combination of AI, Rosetta, and laboratory techniques to accelerate biologics discovery.
Industries
Nr. of Employees
small (1-50)
Cyrus Biotechnology
3005 1st Ave, Suite 203, Seattle, WA 98121
Products
Engineered IgG-degrading protease candidate for IgG-mediated autoimmune disease
A protease biologic engineered to rapidly cleave IgG, optimized for extended half-life and reduced immunogenicity with preclinical evidence of redosability and low anti-drug antibody responses.
IL-22 fusion protein engineered for enhanced activity
An engineered IL-22 fusion designed to overcome endogenous binding protein inhibition for potential autoimmune gastrointestinal and metabolic indications.
ACE2-based decoy receptor Fc-fusion prophylactic candidate against SARS-CoV-2 variants
A soluble receptor-Fc fusion engineered for durable prophylaxis against SARS-CoV-2, optimized for manufacturability, variant resistance, and target affinity.
Engineered IgG-degrading protease candidate for IgG-mediated autoimmune disease
A protease biologic engineered to rapidly cleave IgG, optimized for extended half-life and reduced immunogenicity with preclinical evidence of redosability and low anti-drug antibody responses.
IL-22 fusion protein engineered for enhanced activity
An engineered IL-22 fusion designed to overcome endogenous binding protein inhibition for potential autoimmune gastrointestinal and metabolic indications.
ACE2-based decoy receptor Fc-fusion prophylactic candidate against SARS-CoV-2 variants
A soluble receptor-Fc fusion engineered for durable prophylaxis against SARS-CoV-2, optimized for manufacturability, variant resistance, and target affinity.
Services
Subscription software offering for protein structure prediction, antibody modeling, and integrated design workflows.
Project-based collaborations providing computational design, experimental mutational scanning, assay development, and candidate optimization for partner programs.
Laboratory-based services to generate comprehensive mutational datasets and perform quantitative assays to inform design decisions.
Subscription software offering for protein structure prediction, antibody modeling, and integrated design workflows.
Project-based collaborations providing computational design, experimental mutational scanning, assay development, and candidate optimization for partner programs.
Laboratory-based services to generate comprehensive mutational datasets and perform quantitative assays to inform design decisions.
Expertise Areas
- Computational protein design
- Deep mutational scanning and high-throughput screening
- Antibody structure prediction and engineering
- Immunogenicity risk mitigation
Key Technologies
- AI-driven protein design
- Computational protein structure prediction
- Deep mutational scanning (DMS)
- High-throughput biochemical assays