CoolSpine LLC
CoolSpine™ is a medical device company spun out from Yale University, focused on developing a cerebral spinal fluid cooling platform to induce localized hypothermia. This innovative technology aims to prevent neurological injuries such as paraplegia and brain damage by reducing the effects of spinal cord and cerebral ischemia while maintaining systemic normothermia.
Industries
Nr. of Employees
small (1-50)
CoolSpine LLC
Products
Intrathecal spinal cooling catheter (prototype)
Intrathecal multi-lumen catheter prototype that circulates cold saline in a closed loop to cool CSF and adjacent spinal cord tissue for prevention of ischemic spinal cord injury.
Intraventricular brain cooling catheter (prototype)
Intraventricular multi-lumen catheter prototype that circulates cold saline in a closed loop to cool CSF within the ventricular system to reduce brain tissue temperature for neuroprotection.
Intrathecal spinal cooling catheter (prototype)
Intrathecal multi-lumen catheter prototype that circulates cold saline in a closed loop to cool CSF and adjacent spinal cord tissue for prevention of ischemic spinal cord injury.
Intraventricular brain cooling catheter (prototype)
Intraventricular multi-lumen catheter prototype that circulates cold saline in a closed loop to cool CSF within the ventricular system to reduce brain tissue temperature for neuroprotection.
Services
Development and testing of catheter-based cooling prototypes in large-animal models, with generation of preclinical data for peer-reviewed publication.
Collaboration and licensing arrangements with established medical device companies to develop clinical applications of spinal and brain cooling technologies.
Development and testing of catheter-based cooling prototypes in large-animal models, with generation of preclinical data for peer-reviewed publication.
Collaboration and licensing arrangements with established medical device companies to develop clinical applications of spinal and brain cooling technologies.
Expertise Areas
- Neuroprotection via therapeutic hypothermia
- Catheter-based medical device development
- Preclinical large-animal study execution and publication
- Closed-loop fluid-circulation systems for thermal management
Key Technologies
- Intrathecal catheter cooling
- Intraventricular catheter cooling
- Multi-lumen catheter design
- Closed-loop saline circulation systems
News & Updates
Published in the Journal of Cardiovascular Surgery, this article discusses the development of a cooling catheter for spinal cord preservation.
This article in the Journal of Neurointerventional Surgery details a novel brain cooling catheter designed to mitigate brain injuries.
An abstract discussing the effects of selective brain cooling in a sheep model of neurotrauma.
Published in the Journal of Cardiovascular Surgery, this article discusses the development of a cooling catheter for spinal cord preservation.
This article in the Journal of Neurointerventional Surgery details a novel brain cooling catheter designed to mitigate brain injuries.
An abstract discussing the effects of selective brain cooling in a sheep model of neurotrauma.