CONTINUUS Pharmaceuticals, Inc.
CONTINUUS Pharmaceuticals is a spin-out company from a collaboration between MIT and Novartis, specializing in end-to-end Integrated Continuous Manufacturing (ICM) for pharmaceuticals. Their mission is to produce high-quality drugs more effectively and at a lower cost, transforming pharmaceutical manufacturing from outdated batch systems to state-of-the-art continuous processes. They leverage innovative ICM technology to improve affordability, accessibility, and quality of pharmaceuticals globally, addressing industry challenges such as long lead times, high costs, and quality issues.
Industries
Nr. of Employees
small (1-50)
CONTINUUS Pharmaceuticals, Inc.
Boston, Massachusetts, United States, North America
Products
Integrated extrusion-molding-coating (EMC) system (continuous tablet formation)
An automated integrated system that combines twin-screw hot-melt extrusion and injection molding with optional coating to continuously produce tablets from API and excipient powders, with in-line PAT ports and automated feeders for high-containment operation.
ICM pilot plant (integrated continuous pilot facility)
A pilot-scale integrated continuous manufacturing line that includes dissolution/clarification, reactive crystallization, rotary filtration, drum drying, EMC tablet formation, solvent recovery and a plant-wide control system used for process demonstration, feasibility and multi-day production runs.
Integrated extrusion-molding-coating (EMC) system (continuous tablet formation)
An automated integrated system that combines twin-screw hot-melt extrusion and injection molding with optional coating to continuously produce tablets from API and excipient powders, with in-line PAT ports and automated feeders for high-containment operation.
ICM pilot plant (integrated continuous pilot facility)
A pilot-scale integrated continuous manufacturing line that includes dissolution/clarification, reactive crystallization, rotary filtration, drum drying, EMC tablet formation, solvent recovery and a plant-wide control system used for process demonstration, feasibility and multi-day production runs.
Services
End-to-end continuous process development and manufacturing
Development, piloting and operation of integrated continuous manufacturing lines for small-molecule APIs and oral solid dosage forms, including synthesis, purification, drying and tablet formation using solvent-free hot-processing.
Targeted unit-operation process development (EMC, crystallization, filtration)
Development and optimization of single or modular continuous unit operations (e.g., extrusion-molding-coating, reactive crystallization, rotary filtration, drum drying) that can be integrated into existing or new continuous lines.
PAT deployment and analytical method correlation
Implementation of in-line PAT systems and correlation of PAT outputs with off-line analytical methods (HPLC, XRPD, DSC) and development of model-based predictive dissolution approaches.
Solvent recovery and environmental impact assessment
Design and implementation of solvent recovery systems and process evaluations (E-factor, energy intensity) to reduce solvent usage, waste generation and operating costs.
End-to-end continuous process development and manufacturing
Development, piloting and operation of integrated continuous manufacturing lines for small-molecule APIs and oral solid dosage forms, including synthesis, purification, drying and tablet formation using solvent-free hot-processing.
Targeted unit-operation process development (EMC, crystallization, filtration)
Development and optimization of single or modular continuous unit operations (e.g., extrusion-molding-coating, reactive crystallization, rotary filtration, drum drying) that can be integrated into existing or new continuous lines.
PAT deployment and analytical method correlation
Implementation of in-line PAT systems and correlation of PAT outputs with off-line analytical methods (HPLC, XRPD, DSC) and development of model-based predictive dissolution approaches.
Solvent recovery and environmental impact assessment
Design and implementation of solvent recovery systems and process evaluations (E-factor, energy intensity) to reduce solvent usage, waste generation and operating costs.
Expertise Areas
- Continuous pharmaceutical manufacturing
- Process development and scale-up for small molecules
- Hot-melt extrusion and injection-molding for oral solid dosage forms
- Reactive crystallization and crystallization engineering
Key Technologies
- Integrated extrusion-molding-coating (EMC) system
- Twin-screw hot-melt extrusion (HME)
- Injection molding for tablet formation
- Continuous reactive crystallization (CSTR/PFR cascades)